PMID- 1353554
OWN - NLM
STAT- MEDLINE
DCOM- 19920903
LR  - 20190610
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 340
IP  - 8816
DP  - 1992 Aug 15
TI  - Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy").
PG  - 384-7
AB  - The risk of adverse reactions to 3,4-methylenedioxymethamphetamine (MDMA), more 
      commonly known as "ecstasy", is now widely known in both the USA and UK, but the 
      patterns of illness remain varied. We report our experience during 1990 and 1991. 
      There has been a recent increase in cases of severe toxicity following 
      recreational misuse of small amounts of MDMA. Among 7 fatalities, the pattern of 
      toxicity included fulminant hyperthermia, convulsions, disseminated intravascular 
      coagulation, rhabdomyolysis, and acute renal failure. Until now, there have been 
      few reports of this type of toxicity from MDMA, which may be related both to the 
      potential of the drug to alter thermoregulation and to the circumstances of 
      misuse. In addition, we have monitored 7 cases of hepatotoxicity and suspect that 
      the frequency of this complication is increasing; a history of MDMA misuse should 
      be sought in young people presenting with unexplained jaundice or hepatomegaly. 
      We also describe 5 subjects involved in road traffic accidents in whom MDMA was 
      identified. Misuse of MDMA can have severe acute toxic effects; few data are 
      available concerning long-term morbidity, and this deserves close monitoring in 
      future.
FAU - Henry, J A
AU  - Henry JA
AD  - National Poisons Unit, Guy's Hospital, London, UK.
FAU - Jeffreys, K J
AU  - Jeffreys KJ
FAU - Dawling, S
AU  - Dawling S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
CIN - Lancet. 1992 Sep 19;340(8821):725-6. PMID: 1355817
CIN - Lancet. 1992 Sep 19;340(8821):726. PMID: 1355818
MH  - 3,4-Methylenedioxyamphetamine/adverse effects/*analogs & derivatives/poisoning
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Morbidity
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - *Substance-Related Disorders/epidemiology
EDAT- 1992/08/15 00:00
MHDA- 1992/08/15 00:01
CRDT- 1992/08/15 00:00
PHST- 1992/08/15 00:00 [pubmed]
PHST- 1992/08/15 00:01 [medline]
PHST- 1992/08/15 00:00 [entrez]
AID - 0140-6736(92)91469-O [pii]
AID - 10.1016/0140-6736(92)91469-o [doi]
PST - ppublish
SO  - Lancet. 1992 Aug 15;340(8816):384-7. doi: 10.1016/0140-6736(92)91469-o.