PMID- 1353631
OWN - NLM
STAT- MEDLINE
DCOM- 19920831
LR  - 20190907
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 16
IP  - 4
DP  - 1992 Jul
TI  - Influence of the acute stress on agonist-stimulated phosphoinositide hydrolysis 
      in the rat cerebral cortex.
PG  - 561-70
AB  - 1. The present study was carried out in order to elucidate the influence of the 
      acute stress on alpha 1-adrenergic, serotonin-2 (5-HT2) and muscarinic 
      cholinergic (M-Ach) receptors-mediated phosphoinositide (PI) hydrolysis in rat 
      cerebral cortex slices. 2. In rat cerebral cortex slices, noradrenaline (NA), 
      serotonin (5-HT) and carbachol stimulated [3H]inositol-monophosphate (IP1) 
      accumulation in a concentration-dependent manner. 3. The forced swimming test 
      (FST) for 15 min induced a significant reduction of 5-HT-stimulated [3H]IP1 
      accumulation, but this stress situation did not produce a significant alteration 
      of NA- and carbachol-stimulated [3H]IP1 accumulation. 4. The FST for 15 min did 
      not affect the density and affinity of alpha 1-adrenergic, 5-HT2 and M-Ach 
      receptors. 5. In a mild acute stress situation, the intracellular signal 
      transduction mediated by 5-HT was promptly inhibited as compared to the signal 
      transduction mediated by NA or carbachol. This inhibition may be induced by an 
      acute uncoupling of 5-HT2 receptor-mediated intracellular signal transduction.
FAU - Morinobu, S
AU  - Morinobu S
AD  - Department of Neuro-Psychiatry, Yamagata University School of Medicine, Japan.
FAU - Kuwayama, N
AU  - Kuwayama N
FAU - Kawanami, T
AU  - Kawanami T
FAU - Okuyama, N
AU  - Okuyama N
FAU - Takahashi, M
AU  - Takahashi M
FAU - Totsuka, S
AU  - Totsuka S
FAU - Endoh, M
AU  - Endoh M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 0 (Phosphatidylinositols)
RN  - 0 (Receptors, Muscarinic)
RN  - 0 (Receptors, Serotonin)
SB  - IM
MH  - Adrenergic alpha-Agonists/pharmacology
MH  - Animals
MH  - Cerebral Cortex/drug effects/*metabolism
MH  - Hydrolysis
MH  - In Vitro Techniques
MH  - Male
MH  - Phosphatidylinositols/*metabolism
MH  - Radioligand Assay
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Muscarinic/drug effects
MH  - Receptors, Serotonin/drug effects
MH  - Signal Transduction/physiology
MH  - Stress, Psychological/*metabolism
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1016/0278-5846(92)90061-i [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 1992 Jul;16(4):561-70. doi: 
      10.1016/0278-5846(92)90061-i.