PMID- 1354639
OWN - NLM
STAT- MEDLINE
DCOM- 19920922
LR  - 20190902
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 13
IP  - 4
DP  - 1992 Aug
TI  - Isolation of 1001 new markers from human chromosome 11, excluding the region of 
      11p13-p15.5, and their sublocalization by a new series of radiation-reduced 
      somatic cell hybrids.
PG  - 1133-42
AB  - The determination of the physical map of human chromosome 11 will require more 
      clones than are currently available. We have isolated an additional 1001 new 
      markers in a bacteriophage vector from a somatic cell hybrid cell line that 
      contains most of chromosome 11, except the middle of the short arm. These markers 
      were localized to five different regions, 11p15-pter, 11p12-cen, 11q11-q14, 
      11q14-q23, and 11q23-qter, by a panel of previously characterized somatic cell 
      hybrids. The region 11q11-14 harbors genes that have been shown to be important 
      in breast cancer, B-cell lymphomas, centrocytic lymphomas, asthma, and multiple 
      endocrine neoplasia, type 1 (MEN1). To determine the positions of the recombinant 
      clones located there, we developed a new series of radiation-reduced somatic cell 
      hybrids. These hybrids, together with those previously characterized, allowed us 
      to map the 11q11-q14 markers into 11 separate segregation groups.
FAU - Gerhard, D S
AU  - Gerhard DS
AD  - Department of Genetics, Washington University School of Medicine, St. Louis, 
      Missouri.
FAU - Lawrence, E
AU  - Lawrence E
FAU - Wu, J
AU  - Wu J
FAU - Chua, H
AU  - Chua H
FAU - Ma, N
AU  - Ma N
FAU - Bland, S
AU  - Bland S
FAU - Jones, C
AU  - Jones C
LA  - eng
GR  - CA18734/CA/NCI NIH HHS/United States
GR  - NS26854/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Genetic Markers)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - APO
GS  - HBBC
GS  - HRAS
GS  - IG-FII
GS  - INS
GS  - MEN1
GS  - PGDB
GS  - TH
GS  - THY1
MH  - Asthma/genetics
MH  - Base Sequence
MH  - Blotting, Southern
MH  - Centromere
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - DNA
MH  - *Genetic Markers
MH  - Genetic Vectors
MH  - Humans
MH  - *Hybrid Cells
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia/genetics
MH  - Nucleic Acid Hybridization
MH  - Polymorphism, Restriction Fragment Length
MH  - Radiation
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 10.1016/0888-7543(92)90028-q [doi]
PST - ppublish
SO  - Genomics. 1992 Aug;13(4):1133-42. doi: 10.1016/0888-7543(92)90028-q.