PMID- 1354897
OWN - NLM
STAT- MEDLINE
DCOM- 19920924
LR  - 20191028
IS  - 0270-3211 (Print)
IS  - 0270-3211 (Linking)
VI  - 12
IP  - 1
DP  - 1992
TI  - Tobramycin-induced changes in renal histology of fetal and newborn Sprague-Dawley 
      rats.
PG  - 19-30
AB  - Effects on renal development were studied using tobramycin (TBM) as a model 
      compound. Pregnant Sprague-Dawley rats were injected i.p. with TBM at 30 or 60 
      mg/kg body weight/day on gestational days (GD) 10-19. Kidneys from dams and 
      conceptuses were examined on GD 20 and on postnatal day (PD) 9. The dosing 
      regimen caused in dams moderate proximal tubular alterations and increased 
      concentrations in serum creatinine. Fetal kidneys showed granularity and swelling 
      of proximal tubule cells at the 30 mg/kg dose, poor glomerular differentiation at 
      the 60 mg/kg dose, increased glomerular density at both doses, and no changes on 
      macroscopic examination at either dose. In newborns were observed a moderate 
      developmental delay and tubular lesions at the higher dose, and dose-related 
      increases of glomerular density and relative medullary area at both doses. All 
      findings were more pronounced in males. A maturational disruption of the tubular 
      structures possibly leading to increased glomerular density was attributed to TBM 
      exposure during renal organogenesis in the rat.
FAU - Mantovani, A
AU  - Mantovani A
AD  - Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di 
      Sanita, Rome, Italy.
FAU - Macri, C
AU  - Macri C
FAU - Stazi, A V
AU  - Stazi AV
FAU - Ricciardi, C
AU  - Ricciardi C
FAU - Guastadisegni, C
AU  - Guastadisegni C
FAU - Maranghi, F
AU  - Maranghi F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Teratog Carcinog Mutagen
JT  - Teratogenesis, carcinogenesis, and mutagenesis
JID - 8100917
RN  - AYI8EX34EU (Creatinine)
RN  - VZ8RRZ51VK (Tobramycin)
SB  - IM
MH  - Abnormalities, Drug-Induced/*etiology/pathology
MH  - Animals
MH  - Animals, Newborn
MH  - Creatinine/blood
MH  - Female
MH  - Kidney/abnormalities/*drug effects/embryology/pathology
MH  - Kidney Glomerulus/abnormalities/drug effects/embryology/pathology
MH  - Kidney Tubules, Proximal/abnormalities/drug effects/embryology/pathology
MH  - Male
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains/embryology
MH  - Tobramycin/*toxicity
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1002/tcm.1770120104 [doi]
PST - ppublish
SO  - Teratog Carcinog Mutagen. 1992;12(1):19-30. doi: 10.1002/tcm.1770120104.