PMID- 1354975
OWN - NLM
STAT- MEDLINE
DCOM- 19921001
LR  - 20170214
IS  - 0960-3271 (Print)
IS  - 0960-3271 (Linking)
VI  - 11
IP  - 4
DP  - 1992 Jul
TI  - Sulphur derivative of hexachlorobenzene in human urine.
PG  - 271-3
AB  - Pentachlorothiophenol, a sulphur derivative of the widespread environmental 
      pollutant hexachlorobenzene (HCB) has been detected and quantified in the urine 
      of a human general population with high body burden of HCB. The sulphur 
      derivative was analysed by GLC-MS as pentachlorothioanisole (PCTA) after 
      hydrolysis and methylation of the respective conjugate and was found in 100% of 
      the samples (n = 40) with a mean concentration of 1.85 +/- 0.98 ng ml-1 (mean +/- 
      s.d., range 0.58-4.50 ng ml-1). No correlation with urinary pentachlorophenol 
      (PCP) and no sex-related differences were found. The derivative may originate 
      from the biotransformation of HCB stored in tissues and may be a useful maker of 
      HCB metabolism in humans.
FAU - To-Figueras, J
AU  - To-Figueras J
AD  - Facultat de Medicina, Hospital Clinic i Provincial, Universitat de Barcelona, 
      Spain.
FAU - Gomez-Catalan, J
AU  - Gomez-Catalan J
FAU - Rodamilans, M
AU  - Rodamilans M
FAU - Corbella, J
AU  - Corbella J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Sulfhydryl Compounds)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - 92A1Z48VJB (pentachlorothiophenol)
SB  - IM
MH  - Biotransformation
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hexachlorobenzene/*metabolism/pharmacokinetics
MH  - Humans
MH  - Hydrolysis
MH  - Male
MH  - Methylation
MH  - Sulfhydryl Compounds/*urine
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1177/096032719201100406 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 1992 Jul;11(4):271-3. doi: 10.1177/096032719201100406.