PMID- 1355384
OWN - NLM
STAT- MEDLINE
DCOM- 19921002
LR  - 20171116
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 10
IP  - 1
DP  - 1992 Jul
TI  - Effect of methylxanthine derivatives on T cell activation.
PG  - 19-25
AB  - In a Phase I-II trial examining the effect of prophylactic administration of 
      pentoxifylline (PTX) on bone marrow transplant-associated morbidity, there was an 
      apparent reduction in the incidence and severity of acute graft-versus-host 
      disease. To determine if PTX might be directly immunosuppressive, its effects on 
      T cell activation and proliferation were examined. PTX and several cogeners were 
      found to directly suppress T cell proliferation in response to 
      phytohemagglutinin, to allogeneic cells in a mixed leukocyte reaction, and to 
      cross-linking the CD3 complex. The effects were dose-related and associated with 
      suppression of secretion of tumor necrosis factor-alpha (TNF alpha). However, the 
      inhibition of proliferation was not solely due to this effect since adding excess 
      recombinant TNF alpha did not restore the proliferative response. These data 
      suggest that PTX may be clinically useful in suppressing allogeneic reactions in 
      bone marrow transplantation.
FAU - Singer, J W
AU  - Singer JW
AD  - Marrow Transplant Program, Medical Service, Veterans Affairs Medical Center, 
      Seattle, WA.
FAU - Bianco, J A
AU  - Bianco JA
FAU - Takahashi, G
AU  - Takahashi G
FAU - Simrell, C
AU  - Simrell C
FAU - Petersen, J
AU  - Petersen J
FAU - Andrews, D F 3rd
AU  - Andrews DF 3rd
LA  - eng
GR  - CA1033/CA/NCI NIH HHS/United States
GR  - CA18029/CA/NCI NIH HHS/United States
GR  - HL31782/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD2 Antigens)
RN  - 0 (CD3 Complex)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - SD6QCT3TSU (Pentoxifylline)
SB  - IM
MH  - Antigens, Differentiation, T-Lymphocyte
MH  - Bone Marrow Transplantation/adverse effects/immunology
MH  - CD2 Antigens
MH  - CD3 Complex
MH  - Graft vs Host Disease/prevention & control
MH  - Humans
MH  - In Vitro Techniques
MH  - Lymphocyte Activation/*drug effects
MH  - Lymphocyte Culture Test, Mixed
MH  - Pentoxifylline/*analogs & derivatives/chemistry/*pharmacology
MH  - RNA, Messenger/metabolism
MH  - Receptors, Antigen, T-Cell
MH  - Receptors, Immunologic
MH  - T-Lymphocytes/*drug effects/immunology/metabolism
MH  - Tumor Necrosis Factor-alpha/biosynthesis/pharmacology
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
PST - ppublish
SO  - Bone Marrow Transplant. 1992 Jul;10(1):19-25.