PMID- 1355596
OWN - NLM
STAT- MEDLINE
DCOM- 19921002
LR  - 20190911
IS  - 0143-4179 (Print)
IS  - 0143-4179 (Linking)
VI  - 21
IP  - 4
DP  - 1992 Apr
TI  - Supraspinal administration of [D-Met2]FMRFamide produces a naloxone-sensitive 
      increase in heart rate in unrestrained spontaneously hypertensive rats.
PG  - 201-5
AB  - Intracerebroventricular (i.c.v.) administration of either Phe-Met-Arg-Phe-NH2 
      (FMRFamide; molluscan cardioexcitatory neuropeptide; 3-30 micrograms) or the 
      FMRFamide analog Phe-D-Met-Arg-Phe-NH2 ([D-Met2]FMRFamide; 15 micrograms) to 
      conscious unrestrained spontaneously hypertensive rats (SHR) produced a 
      relatively long lasting (greater than 1 h) increase in heart rate. The increase 
      in heart rate produced by [D-Met2]FMRFamide was attenuated by i.c.v. injection of 
      the opiate antagonist naloxone (2 micrograms). These results extend to a second 
      endpoint an apparent opioid agonist-like (naloxone-reversible) action of 
      [D-Met2]FMRFamide.
FAU - Raffa, R B
AU  - Raffa RB
AD  - Drug Discovery Research, R. W. Johnson Pharmaceutical Research Institute, Spring 
      House, PA 19477-0776.
FAU - Addo, M F
AU  - Addo MF
FAU - Gill, A
AU  - Gill A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Neuropeptides)
RN  - 0 (Neurotransmitter Agents)
RN  - 36B82AMQ7N (Naloxone)
RN  - 64190-70-1 (FMRFamide)
SB  - IM
MH  - Animals
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - FMRFamide
MH  - Heart Rate/*drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Naloxone/*pharmacology
MH  - Neuropeptides/administration & dosage/*pharmacology
MH  - Neurotransmitter Agents/*pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Reference Values
MH  - Spinal Cord/physiology
EDAT- 1992/04/01 00:00
MHDA- 1992/04/01 00:01
CRDT- 1992/04/01 00:00
PHST- 1992/04/01 00:00 [pubmed]
PHST- 1992/04/01 00:01 [medline]
PHST- 1992/04/01 00:00 [entrez]
AID - 0143-4179(92)90023-P [pii]
AID - 10.1016/0143-4179(92)90023-p [doi]
PST - ppublish
SO  - Neuropeptides. 1992 Apr;21(4):201-5. doi: 10.1016/0143-4179(92)90023-p.