PMID- 1355968
OWN - NLM
STAT- MEDLINE
DCOM- 19921016
LR  - 20150311
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 7
IP  - 1
DP  - 1992 Aug
TI  - The effects of MDMA and other methylenedioxy-substituted phenylalkylamines on the 
      structure of rat locomotor activity.
PG  - 15-31
AB  - The effects of acute subcutaneous injections of methylenedioxy-substituted 
      phenylalkylamines in rats were tested in an unconditioned motor behavior paradigm 
      using the Behavioral Pattern Monitor (BPM). Based on a previously developed 
      scaling hypothesis and the associated temporal and spatial scaling exponents 
      (alpha and d), the effects of racemic and S(+) 3,4-methylenedioxyamphetamine 
      (MDA), racemic, S(+) and R(-) 3,4-methylenedioxymethamphetamine (MDMA), racemic 
      N-methyl-1-(1,3-benzodioxol-5yl)-2-butanamine (MBDB), racemic 
      N-ethyl-3,4-methylenedioxyamphetamine (MDEA), 2,5-dimethoxy-4-iodoamphetamine, 
      and methamphetamine were characterized using the d-alpha plane. Three distinct 
      dose-response patterns were observed. 1) S(+) and (+/-)MDA had pronounced 
      dose-dependent effects on the structure of motor behavior, which were 
      characterized by long-straight path movements and minimal changes in the amount 
      of motor behavior. 2) (+/-)MDMA and (+/-)MBDB dose-dependently changed patterns 
      of movements towards long-straight paths together with dose-dependent increases 
      in the amount of motor activity. 3) S(+)MDMA and (+/-)MDEA produced dose-related 
      increases in the amount of motor activity with minimal changes of the movement 
      patterns in the BPM. Comparisons with the existing drug discrimination, operant, 
      and biochemical literature on these compounds lead to the conclusion that the 
      observed effects in the d-alpha plane do not simply reflect the different effects 
      of these compounds as dopamine or serotonin (5-HT) releasers or reuptake 
      inhibitors and do not parallel their different abilities to exhibit 
      hallucinogen-like effects. Instead, indirect 5-HT1 effects appear to contribute 
      substantially to the differential changes in the amount and structure of motor 
      behavior induced by the phenylalkylamines. This conclusion may provide an 
      encouraging rationale to develop postsynaptically effective "entactogens," a 
      potential new drug category as adjunctive psychotherapeutics.
FAU - Paulus, M P
AU  - Paulus MP
AD  - Department of Psychiatry, School of Medicine, University of California, San 
      Diego, La Jolla 92093-0804.
FAU - Geyer, M A
AU  - Geyer MA
LA  - eng
GR  - DA02925/DA/NIDA NIH HHS/United States
GR  - DA06325/DA/NIDA NIH HHS/United States
GR  - MH00188/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/*pharmacology
MH  - Animals
MH  - Isomerism
MH  - Male
MH  - Mathematics
MH  - Models, Neurological
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Structure-Activity Relationship
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
PST - ppublish
SO  - Neuropsychopharmacology. 1992 Aug;7(1):15-31.