PMID- 1356163
OWN - NLM
STAT- MEDLINE
DCOM- 19921022
LR  - 20190817
IS  - 0047-1828 (Print)
IS  - 0047-1828 (Linking)
VI  - 56
IP  - 8
DP  - 1992 Aug
TI  - A questionnaire study of beta-adrenergic blockade in dilated cardiomyopathy in 
      Japan.
PG  - 767-75
AB  - A questionnaire study on the effect of beta-blockade in dilated cardiomyopathy 
      was performed. In 89 cases obtained from 24 institutions, either metoprolol (72 
      patients, 41.4 +/- 29.3 mg/day, 14.1 +/- 13.2 months, mean +/- SD), propranolol 
      (5 patients, 23.8 +/- 24.3 mg/day, 25.0 +/- 25.3 months), carteolol (4 patients, 
      7.5 +/- 2.9 mg/day, 9.0 +/- 2.8 months) or another beta-blockers (8 patients) was 
      administered. Nine patients died during the follow-up period. Overall 
      effectiveness as evaluated by the attending physicians showed improvement in 51 
      patients (57.3%), no change in 26 patients (29.2%), deterioration in 11 patients 
      (12.4%) or was indeterminate in one patient. New York Heart Association (NYHA) 
      functional class improved significantly from 2.6 to 2.3 (p less than 0.01). Heart 
      rate decreased from 83.1 to 70.1 (p less than 0.01). Cardiothoracic ratio 
      decreased from 55.5% to 53.9% (p less than 0.01). Left ventricular ejection 
      fraction of the left ventricle measured by echocardiogram increased from 29.8% to 
      37.8% (p less than 0.01). Exercise tolerance during a treadmill test and 
      ventricular arrhythmias in Holter electrocardiograms improved significantly. 
      There was no change in blood pressure. When the patients in different functional 
      classes were compared, the patients of NYHA class III improved more frequently 
      than those of NYHA class II (69% vs 53% p less than 0.01). Improvement of left 
      ventricular end-diastolic dimension and left ventricular ejection fraction was 
      more prominent in patients of class III than in those of class II. NYHA 
      functional class and cardiothoracic ratio were significantly improved only in 
      class III.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Matsumori, A
AU  - Matsumori A
AD  - Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
FAU - Tominaga, M
AU  - Tominaga M
FAU - Kawai, C
AU  - Kawai C
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn Circ J
JT  - Japanese circulation journal
JID - 7806868
RN  - 0 (Adrenergic beta-Antagonists)
SB  - IM
MH  - Adrenergic beta-Antagonists/*therapeutic use
MH  - Cardiomyopathy, Dilated/*drug therapy
MH  - Data Collection
MH  - Drug Evaluation
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Heart Function Tests
MH  - Humans
MH  - Japan
MH  - Male
MH  - Surveys and Questionnaires
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 10.1253/jcj.56.767 [doi]
PST - ppublish
SO  - Jpn Circ J. 1992 Aug;56(8):767-75. doi: 10.1253/jcj.56.767.