PMID- 1356590
OWN - NLM
STAT- MEDLINE
DCOM- 19921113
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 588
IP  - 2
DP  - 1992 Aug 21
TI  - Alpha 1-adrenergic agonists act on the ventromedial hypothalamus to cause 
      neuronal excitation and lordosis facilitation: electrophysiological and 
      behavioral evidence.
PG  - 237-45
AB  - To see if activation of central alpha 1-adrenergic receptors can cause 
      facilitation of lordosis in rats, the behavioral effects of centrally 
      administered alpha 1-agonists, methoxamine (MA) and phenylephrine (PhE), and 
      related agents were studied. In ovariectomized rats treated with estrogen, 
      infusion of MA, PhE, or a beta-agonist isoproterenol, into the lateral ventricle, 
      or bilateral infusions of MA or PhE into the ventromedial hypothalamus (VMH) 
      facilitated lordosis. Conversely, intra-VMH infusion of the alpha 1-antagonist 
      prazosin (PZ) inhibited lordosis. Intra-VMH infusion of isoproterenol or an alpha 
      2-agonist clonidine, had no effect. Neither was the intra-VMH infusion of MA 
      effective if: (i) the rats were not primed with estrogen; (ii) the tips of the 
      cannulae were outside the VMH; or (iii) it was preceded by an intra-VMH infusion 
      of the alpha 1b-antagonist, chloroethylclonidine (CEC). These results not only 
      verify implications from recent studies that alpha 1-receptors in the 
      hypothalamus are important for lordosis facilitation, but further show that the 
      adrenergic facilitatory effect are: (i) mediated specifically by alpha 1b-subtype 
      of the alpha 1-receptor, (ii) estrogen-dependent, and (iii) site-specific to VMH. 
      To investigate neural mechanisms potentially underlying the lordosis-facilitating 
      effect of alpha 1-activation, the actions of MA and PhE on the electrical 
      activity of single neurons of the ventromedial nucleus of the hypothalamus (VMN) 
      in vitro were studied.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Kow, L M
AU  - Kow LM
AD  - Rockefeller University, Laboratory of Neurobiology and Behavior, New York, NY 
      10021-6399.
FAU - Weesner, G D
AU  - Weesner GD
FAU - Pfaff, D W
AU  - Pfaff DW
LA  - eng
GR  - HD-05751/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 0 (Estrogens)
RN  - 0 (Sympathomimetics)
SB  - IM
MH  - Adrenergic alpha-Agonists/*pharmacology
MH  - Animals
MH  - Electric Stimulation
MH  - Electrophysiology
MH  - Estrogens/pharmacology
MH  - Female
MH  - Injections, Intraventricular
MH  - Neurons/*drug effects
MH  - Ovariectomy
MH  - Posture/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sexual Behavior, Animal/*drug effects
MH  - Sympathomimetics/pharmacology
MH  - Ventromedial Hypothalamic Nucleus/anatomy & histology/*drug effects
EDAT- 1992/08/21 00:00
MHDA- 1992/08/21 00:01
CRDT- 1992/08/21 00:00
PHST- 1992/08/21 00:00 [pubmed]
PHST- 1992/08/21 00:01 [medline]
PHST- 1992/08/21 00:00 [entrez]
AID - 0006-8993(92)91581-X [pii]
AID - 10.1016/0006-8993(92)91581-x [doi]
PST - ppublish
SO  - Brain Res. 1992 Aug 21;588(2):237-45. doi: 10.1016/0006-8993(92)91581-x.