PMID- 1356665
OWN - NLM
STAT- MEDLINE
DCOM- 19921110
LR  - 20190813
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 37
IP  - 2
DP  - 1992 Aug
TI  - A case of multiple endocrine neoplasia: hyperparathyroidism, insulinoma, GRF-oma, 
      hypercalcitoninaemia and intractable peptic ulceration.
PG  - 187-8
AB  - A 42-year-old woman with a family history of multiple endocrine neoplasia type 1 
      (MEN 1) presented with symptomatic hypoglycaemia and peptic ulceration. 
      Investigation revealed an insulinoma, hyperparathyroidism, hypercalcitoninaemia 
      with a positive pentagastrin stimulation test, acromegaly due to a GRF-oma, 
      hyperprolactinaemia and normal serum gastrin levels. Five pancreatic tumours were 
      removed at laparotomy and immunostaining was positive for insulin, calcitonin, 
      somatostatin and glucagon. Post-operatively she developed elevated serum gastrin 
      levels and gross peptic ulceration, despite H2-blockers, and died of 
      gastro-intestinal haemorrhage suggesting that removal of the somatostatinoma may 
      have allowed increased gastrin secretion from a gastrinoma. This case emphasizes 
      the importance of measuring a wide variety of tumour marker peptides in MEN 1 and 
      suggests that caution is required in interpretation of the pentagastrin 
      stimulation test in such cases. Patients with MEN 1 and known peptic ulceration 
      may require perioperative omeprazole treatment even if serum gastrin levels are 
      normal.
FAU - Price, D E
AU  - Price DE
AD  - Leicester Royal Infirmary, UK.
FAU - Absalom, S R
AU  - Absalom SR
FAU - Davidson, K
AU  - Davidson K
FAU - Bolia, A
AU  - Bolia A
FAU - Bell, P R
AU  - Bell PR
FAU - Howlett, T A
AU  - Howlett TA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Biomarkers, Tumor)
RN  - 9007-12-9 (Calcitonin)
RN  - 9034-39-3 (Growth Hormone-Releasing Hormone)
SB  - IM
MH  - Adenoma/diagnosis
MH  - Adult
MH  - Biomarkers, Tumor/analysis
MH  - Calcitonin/blood
MH  - Female
MH  - Growth Hormone-Releasing Hormone/blood
MH  - Humans
MH  - Hyperparathyroidism/diagnosis
MH  - Insulinoma/diagnosis
MH  - Multiple Endocrine Neoplasia/blood/complications/*diagnosis
MH  - Pancreatic Neoplasms/diagnosis
MH  - Peptic Ulcer/etiology
MH  - Pituitary Neoplasms/diagnosis
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 10.1111/j.1365-2265.1992.tb02305.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 1992 Aug;37(2):187-8. doi: 
      10.1111/j.1365-2265.1992.tb02305.x.