PMID- 1356787
OWN - NLM
STAT- MEDLINE
DCOM- 19921113
LR  - 20190623
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 215
IP  - 2-3
DP  - 1992 May 14
TI  - The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, 
      p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a 
      common mechanism blocked by fluoxetine and cocaine.
PG  - 153-60
AB  - The abilities of the substituted amphetamines 3,4-methylenedioxymethamphetamine 
      (MDMA), methamphetamine, p-chloroamphetamine (PCA) and fenfluramine to induce 
      synaptosomal [3H]serotonin (5-HT) release were compared using a novel microassay 
      system. The rank order of release potencies was found to be (+/-)PCA congruent to 
      (+)-fenfluramine greater than (+)-MDMA much greater than (+)-methamphetamine. 
      Combination of two drugs at their EC50 did not cause more release than either 
      drug alone at an equivalent concentration. In addition, the 5-HT uptake blockers 
      fluoxetine and cocaine inhibited the release induced by MDMA, methamphetamine, 
      PCA and fenfluramine to the same percentage. However, threshold concentrations of 
      the substituted amphetamines known to inhibit uptake did not attenuate the 
      release caused by higher concentrations of these compounds. These results 
      suggests that MDMA, methamphetamine, PCA and fenfluramine cause 5-HT release via 
      a common mechanism. Furthermore, these results indicate that the 5-HT uptake 
      blockade induced by these substituted amphetamines in vitro is different from 
      that induced by either fluoxetine or cocaine.
FAU - Berger, U V
AU  - Berger UV
AD  - Department of Biology, New York University, NY 10003.
FAU - Gu, X F
AU  - Gu XF
FAU - Azmitia, E C
AU  - Azmitia EC
LA  - eng
GR  - 271-96-7403/PHS HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Antagonists)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 2DS058H2CF (Fenfluramine)
RN  - 333DO1RDJY (Serotonin)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 64-12-0 (p-Chloroamphetamine)
RN  - 660YQ98I10 (Potassium Chloride)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Calcium/physiology
MH  - Cocaine/*pharmacology
MH  - Fenfluramine/pharmacology
MH  - Fluoxetine/*pharmacology
MH  - In Vitro Techniques
MH  - Male
MH  - Methamphetamine/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Potassium Chloride/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Serotonin/metabolism
MH  - Serotonin/*metabolism
MH  - Serotonin Antagonists
MH  - Synaptosomes/drug effects/metabolism
MH  - p-Chloroamphetamine/pharmacology
EDAT- 1992/05/14 00:00
MHDA- 1992/05/14 00:01
CRDT- 1992/05/14 00:00
PHST- 1992/05/14 00:00 [pubmed]
PHST- 1992/05/14 00:01 [medline]
PHST- 1992/05/14 00:00 [entrez]
AID - 0014-2999(92)90023-W [pii]
AID - 10.1016/0014-2999(92)90023-w [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1992 May 14;215(2-3):153-60. doi: 10.1016/0014-2999(92)90023-w.