PMID- 1357603
OWN - NLM
STAT- MEDLINE
DCOM- 19921106
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 139
IP  - 1
DP  - 1992 May 11
TI  - Activation of quisqualate metabotropic receptors reduces glutamate and 
      GABA-mediated synaptic potentials in the rat striatum.
PG  - 41-4
AB  - The role of quisqualate (QUIS) metabotropic receptors in the synaptic 
      transmission in the striatum was investigated using the cortico-striatal slice 
      preparation. Low concentrations (1-30 microM) of trans-1-amino-cyclopentyl-1,3- 
      dicarboxylic acid (t-ACPD), a selective agonist of QUIS metabotropic receptors, 
      decreased glutamate-mediated synaptic potentials (EPSPs) evoked in the striatum 
      by the stimulation of cortico-striatal fibers. This agonist decreased also 
      GABA-mediated depolarizing synaptic potentials evoked by intrastriatal 
      stimulation in the presence of 6-cyano-7-nitro-quinoxaline-2,3- dione (CNQX); 
      this effect was less potent than the action of t-ACPD on glutamate-mediated 
      potentials. Low concentrations of t-ACPD did not affect the intrinsic membrane 
      properties of striatal neurons and their postsynaptic responses to exogenous 
      glutamate and GABA. Higher concentrations (50-100 microM) to t-ACPD caused 
      membrane depolarizations and inward currents in several neurons. Our data suggest 
      that low concentrations of t-ACPD selectively reduce synaptic transmission while 
      higher concentrations of this agonist may cause a direct excitatory action on 
      striatal neurons.
FAU - Calabresi, P
AU  - Calabresi P
AD  - Clinica Neurologica, Dip. Sanita, II Universita di Roma, Italy.
FAU - Mercuri, N B
AU  - Mercuri NB
FAU - Bernardi, G
AU  - Bernardi G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Glutamates)
RN  - 0 (Neurotoxins)
RN  - 0 (Quinoxalines)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 0TQU7668EI (Cycloleucine)
RN  - 111900-32-4 (1-amino-1,3-dicarboxycyclopentane)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
SB  - IM
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione
MH  - Animals
MH  - Corpus Striatum/drug effects/*physiology
MH  - Cycloleucine/analogs & derivatives/pharmacology
MH  - Glutamates/*physiology
MH  - Glutamic Acid
MH  - In Vitro Techniques
MH  - Neurotoxins/pharmacology
MH  - Quinoxalines/pharmacology
MH  - Rats
MH  - Receptors, AMPA
MH  - Receptors, Neurotransmitter/*drug effects
MH  - Synapses/drug effects/*physiology
MH  - gamma-Aminobutyric Acid/*physiology
EDAT- 1992/05/11 00:00
MHDA- 1992/05/11 00:01
CRDT- 1992/05/11 00:00
PHST- 1992/05/11 00:00 [pubmed]
PHST- 1992/05/11 00:01 [medline]
PHST- 1992/05/11 00:00 [entrez]
AID - 0304-3940(92)90852-X [pii]
AID - 10.1016/0304-3940(92)90852-x [doi]
PST - ppublish
SO  - Neurosci Lett. 1992 May 11;139(1):41-4. doi: 10.1016/0304-3940(92)90852-x.