PMID- 1357675
OWN - NLM
STAT- MEDLINE
DCOM- 19921102
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 43
IP  - 1
DP  - 1992 Sep
TI  - Attenuation of alcohol consumption by MDMA (ecstasy) in two strains of 
      alcohol-preferring rats.
PG  - 103-10
AB  - Alcohol preference and manifestation of alcoholism are thought by many to be 
      associated with serotonin (5-HT) dysfunction in the brain. Thus, experiments were 
      performed to determine the effect of acute and subchronic administration of (+/-) 
      3,4-methylenedioxymethamphetamine (MDMA), an amphetamine analog that stimulates 
      5-HT release, on alcohol preference in two strains of alcohol-preferring rats, 
      the Fawn-Hooded (FH) and alcohol-preferring (P) rats. Rats were individually 
      housed and provided free access to a solution of 10% ethanol, food, and water. 
      Ethanol, food, and water intakes were measured daily. After establishing a stable 
      baseline for ethanol and water intake, each rat was injected SC with a dose of 
      5.0 mg/kg MDMA or an equal volume of saline for 1 or 3 consecutive days. Body 
      temperature was recorded immediately before and 120, 240, and 360 min after MDMA 
      treatment. Ethanol, food, and water intake were measured for the preceding 24 h. 
      Further, to determine the effect of MDMA on alcohol metabolism rats were injected 
      with 5.0 mg/kg MDMA or saline and 15 min later with 2.5 g/kg alcohol. Then, blood 
      alcohol levels were determined at 1, 3, and 5 h after alcohol administration. Our 
      results show that a single administration of 5.0 mg/kg MDMA significantly 
      decreased ethanol intake in both FH and P rats and increased water intake. 
      Subchronic administration of 5.0 mg/kg MDMA for 3 consecutive days significantly 
      attenuated alcohol intake in both strains but only increased water intake in P 
      rats. Administration of MDMA induced hyper- and hypothermia in FH and P rats, 
      respectively. This drug failed to exert any significant effect on the 
      pharmacokinetics of alcohol, indicating a central effect.(ABSTRACT TRUNCATED AT 
      250 WORDS)
FAU - Rezvani, A H
AU  - Rezvani AH
AD  - Skipper Bowles Center for Alcohol Studies, University of North Carolina School of 
      Medicine, Chapel Hill 27514.
FAU - Garges, P L
AU  - Garges PL
FAU - Miller, D B
AU  - Miller DB
FAU - Gordon, C J
AU  - Gordon CJ
LA  - eng
GR  - P50-AA07611/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Alcohol Drinking/*genetics/psychology
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Drinking Behavior/drug effects
MH  - Eating/drug effects
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/physiology
MH  - Species Specificity
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 0091-3057(92)90645-V [pii]
AID - 10.1016/0091-3057(92)90645-v [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1992 Sep;43(1):103-10. doi: 
      10.1016/0091-3057(92)90645-v.