PMID- 1357833
OWN - NLM
STAT- MEDLINE
DCOM- 19921104
LR  - 20190824
IS  - 0364-2313 (Print)
IS  - 0364-2313 (Linking)
VI  - 16
IP  - 4
DP  - 1992 Jul-Aug
TI  - Findings and long-term results of parathyroid surgery in multiple endocrine 
      neoplasia type 1.
PG  - 718-22; discussion 722-3
AB  - Forty-two patients with primary hyperparathyroidism (HPT) of multiple endocrine 
      neoplasia type 1 (MEN-1) were evaluated a mean of 8.9 years after subtotal 
      parathyroid resection (SPX, n = 34) or total parathyroidectomy with 
      autotransplantation to the forearm (TPX, n = 23). TPX as the primary operation 
      revealed asymmetric and mainly nodular enlargement of the parathyroid glands with 
      the presence of at least one normal-size gland in half of the individuals. TPX 
      and SPX were accompanied by resolution of the hypercalcemia in 78% and 38% of the 
      patients. Persistent and recurrent HPT occurred in 22% and 61% of the patients, 
      while hypoparathyroidism requiring oral supplements occurred in 30% and 12% of 
      the patients, respectively. Intact serum parathyroid hormone (PTH) in the arm of 
      parathyroid autograft was high in the normocalcemic patients, somewhat lower in 
      the patients with recurrent HPT, and normal to very low in the hypoparathyroid 
      patients. Ratios of intact PTH between the grafted and non-grafted arms varied 
      from 1 to 56.3, with average of 28.1 in the normocalcemic individuals, 8.2 in the 
      patients with recurrent HPT, and 3.3 in those requiring supplements to maintain 
      normocalcemia. These findings substantiate an 80% to 92% reversal of 
      hypercalcemia during long-term follow-up of MEN-1 patients undergoing total 
      parathyroidectomy or subtotal resection of 3-4 parathyroid glands as primary 
      operative procedures and demonstrate the usefulness of intact serum PTH for 
      functional evaluation of parathyroid autografts.
FAU - Hellman, P
AU  - Hellman P
AD  - Department of Surgery, University Hospital, Uppsala, Sweden.
FAU - Skogseid, B
AU  - Skogseid B
FAU - Juhlin, C
AU  - Juhlin C
FAU - Akerstrom, G
AU  - Akerstrom G
FAU - Rastad, J
AU  - Rastad J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
RN  - 0 (Parathyroid Hormone)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Calcium/blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hyperparathyroidism/etiology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/complications/*surgery
MH  - Parathyroid Glands/surgery/transplantation
MH  - Parathyroid Hormone/blood
MH  - Parathyroidectomy/*methods
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1007/BF02067367 [doi]
PST - ppublish
SO  - World J Surg. 1992 Jul-Aug;16(4):718-22; discussion 722-3. doi: 
      10.1007/BF02067367.