PMID- 1357957
OWN - NLM
STAT- MEDLINE
DCOM- 19921105
LR  - 20190918
IS  - 0095-2990 (Print)
IS  - 0095-2990 (Linking)
VI  - 18
IP  - 3
DP  - 1992
TI  - Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and 
      neuropsychological function?
PG  - 331-41
AB  - 3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a selective serotonin 
      (5-HT) neurotoxin in animals. There is now preliminary evidence in humans of 5-HT 
      deficits associated with extensive use of MDMA. In order to begin to describe the 
      cognitive and mood effects of chronic MDMA use, nine individuals with extensive 
      MDMA use histories were studied. Despite the absence of memory deficits on 
      clinical examination, a pattern of mild-to-moderate impairment was observed on 
      both the Initial and Delayed Paragraph Tests of the Wechsler Memory Scale; eight 
      of the subjects had at least mild impairment on at least one test in the 
      neuropsychological battery. Despite previously reported suggestive evidence of 
      5-HT deficit in this group, none reported depressed mood or met clinical criteria 
      for an affective disorder at the time of testing. These preliminary findings 
      raise concern about possible detrimental effects of MDMA use on 
      neuropsychological function for future systematic study and they highlight 
      important issues regarding the effects of 5-HT deficits on cognitive function and 
      mood regulation.
FAU - Krystal, J H
AU  - Krystal JH
AD  - Psychiatry Service, Yale University School of Medicine, West Haven VA Medical 
      Center, Connecticut 06516.
FAU - Price, L H
AU  - Price LH
FAU - Opsahl, C
AU  - Opsahl C
FAU - Ricaurte, G A
AU  - Ricaurte GA
FAU - Heninger, G R
AU  - Heninger GR
LA  - eng
GR  - MH-00579/MH/NIMH NIH HHS/United States
GR  - MH-25642/MH/NIMH NIH HHS/United States
GR  - MH-36229/MH/NIMH NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Am J Drug Alcohol Abuse
JT  - The American journal of drug and alcohol abuse
JID - 7502510
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives
MH  - Adult
MH  - Cognition Disorders/diagnosis/etiology/physiopathology
MH  - Depressive Disorder/diagnosis/*etiology/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - *Neuropsychological Tests
MH  - Serotonin/physiology
MH  - Substance-Related Disorders/*complications/diagnosis/physiopathology
MH  - Wechsler Scales
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.3109/00952999209026070 [doi]
PST - ppublish
SO  - Am J Drug Alcohol Abuse. 1992;18(3):331-41. doi: 10.3109/00952999209026070.