PMID- 1358148
OWN - NLM
STAT- MEDLINE
DCOM- 19921127
LR  - 20170214
IS  - 0960-3271 (Print)
IS  - 0960-3271 (Linking)
VI  - 11
IP  - 5
DP  - 1992 Sep
TI  - Individual differences in activity of glutathione peroxidase and catalase studied 
      in monozygotic twins discordant for smoking.
PG  - 341-6
AB  - 1. Cigarette smoke contains free radicals. The enzymes glutathione peroxidase 
      (GSH-px) and catalase are important parts of the anti-oxidative protecting 
      system. 2. Ten pairs of monozygotic twins, who were discordant for smoking, were 
      analysed in order to determine their erythrocyte glutathione peroxidase and 
      catalase activities and their plasma concentrations of selenium. 3. Analysis of 
      variance (ANOVA) revealed that the difference in activities of catalase and 
      glutathione peroxidase was much less within pairs than between pairs, indicating 
      a large individual variation due to genetic expression or shared environment and 
      no major effect from smoking. 4. The plasma selenium levels of the investigated 
      twins revealed sufficient intake of selenium to maintain maximal activity of 
      GSH-px in erythrocytes. The mean +/- s.d. selenium concentration in plasma for 
      smokers was 98 +/- 16 micrograms l-1 and for non-smokers 111 +/- 16 micrograms 
      l-1. There was no correlation between plasma selenium and glutathione peroxidase 
      in erythrocytes.
FAU - Bjorkman, L
AU  - Bjorkman L
AD  - Department of Environmental Hygiene, Karolinska Institutet, Stockholm, Sweden.
FAU - Svartengren, M
AU  - Svartengren M
FAU - Nordberg, M
AU  - Nordberg M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Catalase/*blood
MH  - Erythrocytes/enzymology
MH  - Female
MH  - Glutathione Peroxidase/*blood
MH  - Humans
MH  - Individuality
MH  - Male
MH  - Middle Aged
MH  - Quality Control
MH  - Selenium/blood
MH  - Smoking/*metabolism
MH  - *Twins, Monozygotic
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1177/096032719201100507 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 1992 Sep;11(5):341-6. doi: 10.1177/096032719201100507.