PMID- 1358429
OWN - NLM
STAT- MEDLINE
DCOM- 19921222
LR  - 20190815
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 63
IP  - 1
DP  - 1992 Oct 1
TI  - Cytogenetics of multiple endocrine neoplasia syndrome. II. Chromosome 
      abnormalities in an insulinoma and a glucagonoma from two subjects with MEN1.
PG  - 17-21
AB  - Cytogenetic analysis of two pancreatic islet tumors, an insulinoma and a 
      glucagonoma was ascertained in two subjects with multiple endocrine neoplasia 
      type 1 (MEN1). The insulinoma had a modal peak at 84 chromosomes. Most cells were 
      pseudotetraploid, and in all cells the normal chromosomes were represented in 
      varied numbers, i.e., from 1 to 7 copies. The tumor had 5 characteristic and 
      consistent marker chromosomes which were identified as deletions of chromosomes 
      1, 2, 7, 16, and 17. All metaphases had several double minute chromosomes (dmin) 
      of variable size and possible intermediate structures between dmin and 
      homogeneously staining chromosomal regions. The glucagonoma had a nearly equal 
      proportion of normal metaphases and metaphases with structural and numerical 
      abnormalities with no consistent trend.
FAU - Scappaticci, S
AU  - Scappaticci S
AD  - Universita di Pavia, Italy.
FAU - Brandi, M L
AU  - Brandi ML
FAU - Capra, E
AU  - Capra E
FAU - Cortinovis, M
AU  - Cortinovis M
FAU - Maraschio, P
AU  - Maraschio P
FAU - Fraccaro, M
AU  - Fraccaro M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 16
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 2
MH  - Chromosomes, Human, Pair 7
MH  - Female
MH  - Glucagonoma/*genetics
MH  - Humans
MH  - Insulinoma/*genetics
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/*genetics
MH  - Pancreatic Neoplasms/genetics
MH  - Polyploidy
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
AID - 0165-4608(92)90057-F [pii]
AID - 10.1016/0165-4608(92)90057-f [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1992 Oct 1;63(1):17-21. doi: 
      10.1016/0165-4608(92)90057-f.