PMID- 1358767
OWN - NLM
STAT- MEDLINE
DCOM- 19921203
LR  - 20190501
IS  - 0017-5749 (Print)
IS  - 1458-3288 (Electronic)
IS  - 0017-5749 (Linking)
VI  - 33
IP  - 9
DP  - 1992 Sep
TI  - Influence of multiple endocrine neoplasia type 1 on gastric endocrine cells in 
      patients with the Zollinger-Ellison syndrome.
PG  - 1275-9
AB  - The influences of multiple endocrine neoplasia type 1 (MEN 1), hypergastrinaemia, 
      age, and sex on gastric endocrine cell densities were studied in 48 patients with 
      the Zollinger-Ellison syndrome of either the sporadic type (n = 31) or associated 
      with MEN 1 (n = 17). The mean fundic argyrophil cell density was higher in women 
      (p < 0.05). It showed no appreciable difference between young and old women but 
      it declined with age in men. The mean argyrophil cell density, when adjusted for 
      sex, was higher (+48.5%, p = 0.06) in patients with Zollinger-Ellison syndrome 
      associated with MEN 1 than in those with sporadic type disease. This measurement 
      was not significantly different between the two groups of patients when 
      antisecretory treatments were considered. In patients with sporadic type disease, 
      fundic argyrophil cells showed a normal pattern (16%) or diffuse (71%) or linear 
      (13%) hyperplasia. In patients with MEN 1 diffuse and linear hyperplasia were of 
      the same order (53% and 47%). Furthermore, fundic argyrophil endocrine tumours 
      developed in five of 17-that is, 29.5% of patients with associated MEN 1 while 
      none was seen in patients with sporadic type disease. These tumours showed an 
      exclusive or prominent enterochromaffin like cell population. Antral gastrin and 
      somatostatin cell densities and fasting serum gastrin concentrations were similar 
      in the two groups of patients with Zollinger-Ellison syndrome. Whatever the 
      underlying mechanism for carcinoidosis, the risk of developing fundic 
      enterochromaffin like cell tumours in Zollinger-Ellison syndrome patients who 
      present with MEN 1 is probably higher than was initially estimated and suggests 
      that regular follow up of these patients is necessary.
FAU - Lehy, T
AU  - Lehy T
AD  - INSERM Unite 10, Hopital Bichat, Paris, France.
FAU - Cadiot, G
AU  - Cadiot G
FAU - Mignon, M
AU  - Mignon M
FAU - Ruszniewski, P
AU  - Ruszniewski P
FAU - Bonfils, S
AU  - Bonfils S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
RN  - 0 (Gastrins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Count
MH  - Female
MH  - Gastrins/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/complications/*pathology
MH  - Sex Factors
MH  - Stomach/*pathology
MH  - Zollinger-Ellison Syndrome/etiology/*pathology
PMC - PMC1379501
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
PMCR- 1992/09/01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
PHST- 1992/09/01 00:00 [pmc-release]
AID - 10.1136/gut.33.9.1275 [doi]
PST - ppublish
SO  - Gut. 1992 Sep;33(9):1275-9. doi: 10.1136/gut.33.9.1275.