PMID- 1358810
OWN - NLM
STAT- MEDLINE
DCOM- 19921217
LR  - 20190902
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 14
IP  - 3
DP  - 1992 Nov
TI  - Pax1, a member of the paired box-containing class of developmental control genes, 
      is mapped to human chromosome 20p11.2 by in situ hybridization (ISH and FISH).
PG  - 740-4
AB  - Pax-1, a member of a murine multigene family, belongs to the paired 
      box-containing class of developmental control genes first identified in 
      Drosophila. The Pax-1 gene encodes a sequence-specific DNA-binding protein with 
      transcriptional activating properties and has been found to be mutated in the 
      autosomal recessive mutation undulated (un) on mouse chromosome 2 with vertebral 
      anomalies along the entire rostrocaudal axis. By radioactive in situ 
      hybridization (ISH) using a fragment from the murine Pax-1 paired box that is 
      almost identical to the respective sequences from the cognate human gene HuP48 
      and fluorescence in situ hybridization (FISH) using a complete mouse Pax-1 cDNA, 
      we have assigned the human homologue of murine Pax-1, the PAX1 locus, to 
      chromosome 20p. The map position of PAX1 after FISH (FL-pter value of 0.34 +/- 
      0.04) corresponds to band p11.2. These results confirm the exceptional homology 
      between human chromosome 20 and the distal segment of mouse chromosome 2, 
      extending from bands F to G, and add PAX1 to the group of genes on 20p like PTPA, 
      PRNP, SCG1, BMP2A, which are located in proximity on both chromosomes.
FAU - Schnittger, S
AU  - Schnittger S
AD  - Institut fur Humangenetik, Universitat Gottingen, Germany.
FAU - Rao, V V
AU  - Rao VV
FAU - Deutsch, U
AU  - Deutsch U
FAU - Gruss, P
AU  - Gruss P
FAU - Balling, R
AU  - Balling R
FAU - Hansmann, I
AU  - Hansmann I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (Transcription Factors)
RN  - 142661-96-9 (PAX1 transcription factor)
SB  - IM
MH  - Animals
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 20
MH  - Cricetinae
MH  - DNA-Binding Proteins/*genetics
MH  - *Genes, Homeobox
MH  - Humans
MH  - Hybrid Cells
MH  - In Situ Hybridization
MH  - In Situ Hybridization, Fluorescence
MH  - Paired Box Transcription Factors
MH  - Transcription Factors/*genetics
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
AID - 10.1016/s0888-7543(05)80177-6 [doi]
PST - ppublish
SO  - Genomics. 1992 Nov;14(3):740-4. doi: 10.1016/s0888-7543(05)80177-6.