PMID- 1361317
OWN - NLM
STAT- MEDLINE
DCOM- 19930121
LR  - 20190503
IS  - 0003-4967 (Print)
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 51
IP  - 11
DP  - 1992 Nov
TI  - Sulphasalazine inhibition of human granulocyte activation by inhibition of second 
      messenger compounds.
PG  - 1230-6
AB  - The effects of sulphasalazine on the production of second messenger compounds in 
      human granulocytes have been characterised by various stimuli. The increases in 
      cytosolic calcium, inositol trisphosphate, diacylglycerol, and phosphatidic acid 
      (all important mediators of intracellular signal transduction) triggered by 
      stimulation were inhibited by sulphasalazine. The metabolites 5-amino-salicylic 
      acid and sulphapyridine were less potent inhibitors than the mother compound. It 
      is concluded that sulphasalazine inhibits the synthesis of phosphoinositide 
      derived second messenger compounds at the level of phospholipase C or its 
      regulatory guanosine 5'-triphosphate (GTP) binding protein. Inhibition of 
      phosphatidic acid synthesis was either due to the same mechanism, or to 
      interaction with a phospholipase D regulating GTP binding protein.
FAU - Carlin, G
AU  - Carlin G
AD  - Department of Pharmacology, Kabi Pharmacia Therapeutics, Uppsala, Sweden.
FAU - Djursater, R
AU  - Djursater R
FAU - Smedegard, G
AU  - Smedegard G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Aminosalicylic Acids)
RN  - 0 (Phosphatidic Acids)
RN  - 0 (Phosphatidylinositols)
RN  - 3XC8GUZ6CB (Sulfasalazine)
RN  - 4Q81I59GXC (Mesalamine)
RN  - 85166-31-0 (Inositol 1,4,5-Trisphosphate)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - SY7Q814VUP (Calcium)
RN  - Y5V2N1KE8U (Sulfapyridine)
SB  - IM
MH  - Aminosalicylic Acids/pharmacology
MH  - Calcium/metabolism
MH  - Cells, Cultured
MH  - Cytosol/metabolism
MH  - Depression, Chemical
MH  - Granulocytes/drug effects/*metabolism/physiology
MH  - Guanosine Triphosphate/pharmacology
MH  - Humans
MH  - Inositol 1,4,5-Trisphosphate/biosynthesis
MH  - Mesalamine
MH  - Phosphatidic Acids/biosynthesis
MH  - Phosphatidylinositols/*metabolism
MH  - Second Messenger Systems/*drug effects
MH  - Sulfapyridine/pharmacology
MH  - Sulfasalazine/*pharmacology
PMC - PMC1012461
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
PMCR- 1995/11/01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
PHST- 1995/11/01 00:00 [pmc-release]
AID - 10.1136/ard.51.11.1230 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 1992 Nov;51(11):1230-6. doi: 10.1136/ard.51.11.1230.