PMID- 1361410
OWN - NLM
STAT- MEDLINE
DCOM- 19930126
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 595
IP  - 1
DP  - 1992 Nov 6
TI  - The N-methyl-D-aspartate antagonist MK-801 protects against serotonin depletions 
      induced by methamphetamine, 3,4-methylenedioxymethamphetamine and 
      p-chloroamphetamine.
PG  - 121-7
AB  - The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 blocks 
      the ability of D-methamphetamine (MA) to deplete striatal dopamine (DA). We now 
      report that MK-801 attenuates decreases in serotonin (5-HT) concentration induced 
      by MA and two other amphetamine analogues, 3,4-methylenedioxymethamphetamine 
      (MDMA) and p-chloroamphetamine (PCA). Rats were injected with saline (1.0 ml/kg) 
      or MK-801 (0.5, 1.0 or 2.5 mg/kg) followed by either saline (1.0 mg/kg), MA (4, 2 
      or 1 injection(s); 10.0, 20.0 or 40.0 mg/kg), MDMA (20.0 or 40.0 mg/kg) or PCA 
      (5.0 or 10.0 mg/kg). In some experiments, two injections of MK-801 or saline were 
      used. Seventy-two hours after the last injection rats were sacrificed and 
      concentrations of 5-HT, 5-hydroxyindoleacetic acid (5-HIAA) and DA were 
      determined in hippocampus and striatum. MA caused a depletion of 5-HT to 33% of 
      control in hippocampus and to 50% of control in striatum after the 4 x 10.0 mg/kg 
      dose regimen. When MK-801 (2.5 mg/kg) was co-administered with MA, concentrations 
      of 5-HT did not differ from control levels in either brain region. MDMA depleted 
      5-HT to approximately 58% of control in hippocampus and 66% of control in 
      striatum at the 40 mg/kg dose.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Farfel, G M
AU  - Farfel GM
AD  - University of Chicago, Department of Pharmacological and Physiological Sciences, 
      IL 60637.
FAU - Vosmer, G L
AU  - Vosmer GL
FAU - Seiden, L S
AU  - Seiden LS
LA  - eng
GR  - DA-00085/DA/NIDA NIH HHS/United States
GR  - MH-10562/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 333DO1RDJY (Serotonin)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 64-12-0 (p-Chloroamphetamine)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/antagonists & 
      inhibitors/pharmacology
MH  - Animals
MH  - Corpus Striatum/drug effects/metabolism
MH  - Dizocilpine Maleate/*pharmacology
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Methamphetamine/*antagonists & inhibitors/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - N-Methylaspartate/*antagonists & inhibitors
MH  - Rats
MH  - Serotonin/*metabolism
MH  - p-Chloroamphetamine/*antagonists & inhibitors/pharmacology
EDAT- 1992/11/06 00:00
MHDA- 1992/11/06 00:01
CRDT- 1992/11/06 00:00
PHST- 1992/11/06 00:00 [pubmed]
PHST- 1992/11/06 00:01 [medline]
PHST- 1992/11/06 00:00 [entrez]
AID - 0006-8993(92)91460-V [pii]
AID - 10.1016/0006-8993(92)91460-v [doi]
PST - ppublish
SO  - Brain Res. 1992 Nov 6;595(1):121-7. doi: 10.1016/0006-8993(92)91460-v.