PMID- 1361978
OWN - NLM
STAT- MEDLINE
DCOM- 19930129
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 146
IP  - 1
DP  - 1992 Oct 26
TI  - Reduction of somatostatin receptors in rat hippocampus by treatment with 
      5,7-dihydroxytryptamine.
PG  - 60-4
AB  - Several lines of evidence suggest that somatostatin (SS) may interact with 
      serotonergic neurons in the central nervous system. To assess whether SS acts 
      presynaptically on serotonin (5-hydroxytryptamine, (5-HT)) neurons, SS receptors 
      were measured in membranes from the hippocampus, a brain region that receives 
      dense serotonergic innervation and has a high number of SS receptors in control 
      and 5,7-dihydroxytryptamine (5,7-DHT)-treated rats, at 1 and 3 weeks after 
      injection. Intracerebroventricular (i.c.v.) injection of the 5-HT-specific 
      neurotoxin 5,7-DHT (11 micrograms (free base) dissolved in 10 microliters of 
      isotonic saline containing 0.01% ascorbic acid) produced a 70% reduction in 
      hippocampal 5-HT content at 3 weeks after injection but not at 1 week. This 
      change was associated with a significant decrease in SS receptor density in rat 
      hippocampus only at 3 weeks following the injection, without influencing the 
      apparent affinity of the receptors at any time. Administration of 5,7-DHT did not 
      affect somatostatin-like immunoreactivity (SSLI) levels at both times studied. 
      These results suggest that some of the hippocampal SS receptors may be localized 
      presynaptically on the serotonergic nerve terminals.
FAU - Munoz-Acedo, G
AU  - Munoz-Acedo G
AD  - Department of Biochemistry and Molecular Biology, Medical School, University of 
      Alcala, Madrid, Spain.
FAU - Lopez-Sanudo, S
AU  - Lopez-Sanudo S
FAU - Arilla, E
AU  - Arilla E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Receptors, Somatostatin)
RN  - 31363-74-3 (5,7-Dihydroxytryptamine)
RN  - 333DO1RDJY (Serotonin)
RN  - 51110-01-1 (Somatostatin)
RN  - TG537D343B (Desipramine)
SB  - IM
MH  - 5,7-Dihydroxytryptamine/*pharmacology
MH  - Animals
MH  - Desipramine/pharmacology
MH  - Hippocampus/drug effects/*metabolism
MH  - Injections, Intraventricular
MH  - Membranes/drug effects/metabolism
MH  - Nerve Endings/drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Somatostatin/*metabolism
MH  - Serotonin/immunology/metabolism
MH  - Somatostatin/metabolism
EDAT- 1992/10/26 00:00
MHDA- 1992/10/26 00:01
CRDT- 1992/10/26 00:00
PHST- 1992/10/26 00:00 [pubmed]
PHST- 1992/10/26 00:01 [medline]
PHST- 1992/10/26 00:00 [entrez]
AID - 0304-3940(92)90172-4 [pii]
AID - 10.1016/0304-3940(92)90172-4 [doi]
PST - ppublish
SO  - Neurosci Lett. 1992 Oct 26;146(1):60-4. doi: 10.1016/0304-3940(92)90172-4.