PMID- 1362085
OWN - NLM
STAT- MEDLINE
DCOM- 19930211
LR  - 20190815
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 32
IP  - 12
DP  - 1992 Dec 15
TI  - Initial studies of embryonic transplants of human hippocampus and cerebral cortex 
      derived from schizophrenic women.
PG  - 1148-63
AB  - Human fetal brain tissue was obtained from first-trimester elective abortions of 
      two women who also had schizophrenia. Portions of the embryonic hippocampus or 
      cerebral cortex were transplanted into the anterior eye chamber of 
      immunologically compromised athymic nude rats. In this environment, embryonic 
      brain tissue derived from normal women generally continues organotypic growth and 
      development for many months. Although initial survival after transplantation was 
      normal, the tissue derived from schizophrenic women manifested less robust 
      growth. However, cells in the transplants showed typical neuronal 
      differentiation, with development of different neuronal types, such as pyramidal 
      cells, granule cells, and gamma-aminobutyric acid (GABA)-containing interneurons. 
      Rhythmic electrical activity was also observed, indicative of some local synaptic 
      organization. The presence of messenger RNA (mRNA) for brain-derived 
      neuronotrophic factor (BDNF) was observed using in situ hybridization. The reason 
      for the decreased rate of growth of these transplants remains unknown and the 
      significance of the finding cannot be assessed from only two fetuses. However, 
      these preliminary findings suggest that fetal transplants may be a useful model 
      system for the detection of developmental pathogenic processes in the expression 
      and transmission of schizophrenia.
FAU - Freedman, R
AU  - Freedman R
AD  - Department of Histology and Neurobiology, Karolinska Institute, Huddinge 
      University Hospital, Stockholm, Sweden.
FAU - Stromberg, I
AU  - Stromberg I
FAU - Seiger, A
AU  - Seiger A
FAU - Olson, L
AU  - Olson L
FAU - Nordstrom, A L
AU  - Nordstrom AL
FAU - Wiesel, F A
AU  - Wiesel FA
FAU - Bygdeman, M
AU  - Bygdeman M
FAU - Wetmore, C
AU  - Wetmore C
FAU - Palmer, M R
AU  - Palmer MR
FAU - Hoffer, B J
AU  - Hoffer BJ
LA  - eng
GR  - MH-00289/MH/NIMH NIH HHS/United States
GR  - MH-38231/MH/NIMH NIH HHS/United States
GR  - MH-44212/MH/NIMH NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Brain Tissue Transplantation/*physiology
MH  - Brain-Derived Neurotrophic Factor
MH  - Cerebral Cortex/physiopathology/*transplantation
MH  - Female
MH  - Fetal Tissue Transplantation/*physiology
MH  - Fluorescent Antibody Technique
MH  - Gene Expression Regulation/physiology
MH  - Graft Survival/genetics/physiology
MH  - Hippocampus/physiopathology/*transplantation
MH  - Humans
MH  - Nerve Growth Factors/genetics/physiology
MH  - Nerve Tissue Proteins/genetics/physiology
MH  - Neurons/physiology
MH  - Nucleic Acid Hybridization
MH  - Pregnancy
MH  - Rats
MH  - Rats, Nude
MH  - Schizophrenia/*genetics/physiopathology
MH  - *Schizophrenic Psychology
MH  - Synaptic Transmission/genetics/physiology
MH  - Transplantation, Heterologous
MH  - Tyrosine 3-Monooxygenase/genetics/physiology
MH  - gamma-Aminobutyric Acid/genetics/physiology
EDAT- 1992/12/15 00:00
MHDA- 1992/12/15 00:01
CRDT- 1992/12/15 00:00
PHST- 1992/12/15 00:00 [pubmed]
PHST- 1992/12/15 00:01 [medline]
PHST- 1992/12/15 00:00 [entrez]
AID - 0006-3223(92)90194-5 [pii]
AID - 10.1016/0006-3223(92)90194-5 [doi]
PST - ppublish
SO  - Biol Psychiatry. 1992 Dec 15;32(12):1148-63. doi: 10.1016/0006-3223(92)90194-5.