PMID- 1362396
OWN - NLM
STAT- MEDLINE
DCOM- 19930217
LR  - 20101118
IS  - 0018-0416 (Print)
IS  - 0018-0416 (Linking)
VI  - 40
IP  - 3-4
DP  - 1992
TI  - Sublocalization of the multiple endocrine neoplasia type 1 gene.
PG  - 159-61
AB  - Tumorigenesis in multiple endocrine neoplasia type 1 (MEN 1) involves the 
      unmasking of a recessive mutation at the MEN 1 locus which has been mapped to 
      chromosomal region 11q11-13. By analyzing 58 DNA markers on a panel of 
      radiation-reduced somatic cell hybrids, the region encompassing the MEN 1 gene 
      was divided into nine subregions. Pulsed field gel electrophoresis analysis of 
      markers within subgroups showed that the recombination rate around the MEN 1 
      locus is high. Combined linkage analysis in MEN 1 families and deletion mapping 
      in MEN 1-related tumors suggest the MEN 1 gene is located centromeric to D11S807 
      and telomeric to PYGM.
FAU - Larsson, C
AU  - Larsson C
AD  - Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden.
FAU - Weber, G
AU  - Weber G
FAU - Janson, M
AU  - Janson M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Henry Ford Hosp Med J
JT  - Henry Ford Hospital medical journal
JID - 0122304
SB  - IM
GS  - MEN1
MH  - Animals
MH  - Chromosome Deletion
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Cricetinae
MH  - Cricetulus
MH  - Genetic Linkage
MH  - Humans
MH  - Multiple Endocrine Neoplasia/*genetics
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Henry Ford Hosp Med J. 1992;40(3-4):159-61.