PMID- 1362397
OWN - NLM
STAT- MEDLINE
DCOM- 19930217
LR  - 20220129
IS  - 0018-0416 (Print)
IS  - 0018-0416 (Linking)
VI  - 40
IP  - 3-4
DP  - 1992
TI  - Molecular genetic mapping of the multiple endocrine neoplasia type 1 locus.
PG  - 162-6
AB  - Familial multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant 
      disorder characterized by the combined occurrence of tumors of the parathyroid 
      glands, the endocrine pancreas, and the pituitary gland. MEN 1 tumors have 
      previously been shown to be associated with the loss of alleles on chromosome 11, 
      and deletion mapping studies together with family linkage studies have localized 
      the MEN 1 gene to 11q13. A detailed genetic map around the MEN 1 locus is 
      required to facilitate further characterization and cloning of the gene (MEN1). 
      We have characterized a panel of seven rodent-human somatic cell hybrids which 
      contain fragments of human chromosome 11 with breakpoints in the pericentromeric 
      region by using eight DNA sequences (D11S149, PGA, PYGM, D11S97, INT2, D11S37, 
      D11S533, and D11S147) to define the region containing MEN1. This will facilitate 
      the rapid localization of additional DNA sequences in this region. In addition, 
      we have used a highly polymorphic repetitive degenerate hexanucleotide sequence, 
      designated D11S533, for segregation studies in one family with MEN 1. These 
      molecular genetic approaches will help to define a precise 1 to 2 centiMorgan map 
      around MEN1.
FAU - Pang, J T
AU  - Pang JT
AD  - Division of Molecular Medicine, MRC Clinical Research Centre, Harrow, Middlesex, 
      United Kingdom.
FAU - Pook, M A
AU  - Pook MA
FAU - Eubanks, J H
AU  - Eubanks JH
FAU - Jones, C
AU  - Jones C
FAU - van Heyningen, V
AU  - van Heyningen V
FAU - Evans, G A
AU  - Evans GA
FAU - Thakker, R V
AU  - Thakker RV
LA  - eng
GR  - MC_U127527199/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Henry Ford Hosp Med J
JT  - Henry Ford Hospital medical journal
JID - 0122304
SB  - IM
GS  - MEN1
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Humans
MH  - Hybrid Cells
MH  - Multiple Endocrine Neoplasia/*genetics
MH  - Nucleic Acid Hybridization
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Repetitive Sequences, Nucleic Acid/genetics
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Henry Ford Hosp Med J. 1992;40(3-4):162-6.