PMID- 1362400
OWN - NLM
STAT- MEDLINE
DCOM- 19930217
LR  - 20171116
IS  - 0018-0416 (Print)
IS  - 0018-0416 (Linking)
VI  - 40
IP  - 3-4
DP  - 1992
TI  - Practical guidelines for DNA-based testing in multiple endocrine neoplasia type 
      1.
PG  - 173-6
AB  - Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant 
      predisposition to neoplastic lesions of the parathyroid glands, the 
      neuroendocrine pancreas, and the anterior pituitary gland. The predisposing 
      genetic defect was localized to the long arm of chromosome 11 by genetic linkage 
      analysis in three affected families. By analyzing six MEN 1 families with 14 DNA 
      marker systems located close to the MEN 1 gene, we have developed a method to 
      identify carriers of the MEN 1 predisposition. We describe practical aspects of 
      such DNA-based diagnostic procedures.
FAU - Larsson, C
AU  - Larsson C
AD  - Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden.
FAU - Nordenskjold, M
AU  - Nordenskjold M
FAU - Skogseid, B
AU  - Skogseid B
FAU - Oberg, K
AU  - Oberg K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Henry Ford Hosp Med J
JT  - Henry Ford Hospital medical journal
JID - 0122304
RN  - 0 (DNA Probes)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Genetic Markers)
SB  - IM
GS  - MEN1
MH  - Blotting, Southern
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11
MH  - *DNA Probes
MH  - DNA, Neoplasm/genetics
MH  - Genetic Carrier Screening
MH  - Genetic Markers
MH  - Humans
MH  - Multiple Endocrine Neoplasia/*diagnosis/genetics
MH  - Polymorphism, Genetic
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Henry Ford Hosp Med J. 1992;40(3-4):173-6.