PMID- 1362402
OWN - NLM
STAT- MEDLINE
DCOM- 19930217
LR  - 20131121
IS  - 0018-0416 (Print)
IS  - 0018-0416 (Linking)
VI  - 40
IP  - 3-4
DP  - 1992
TI  - Hyperparathyroidism with normal albumin-corrected total calcium in patients with 
      multiple endocrine neoplasia type 1.
PG  - 186-90
AB  - In the largest reported family of patients with multiple endocrine neoplasia type 
      1 (MEN 1), hyperparathyroidism was expressed at first screening in 33 patients by 
      elevation of ionized calcium (IC) (30 cases) or parathyroid hormone (three cases) 
      without elevation of albumin-corrected total calcium (ACTC). Three of these 33 
      patients have shown a progressive rise in IC and later an elevation of ACTC. 
      However, the age distribution suggests that in others the level of IC may remain 
      stable at a minimally elevated level throughout life with ACTC remaining normal 
      except for transient rises at the times of intercurrent illness or surgical 
      operation. Even when ACTC is normal preoperatively, patients with an elevation of 
      IC require radical subtotal parathyroidectomy or total parathyroidectomy and 
      forearm implantation to restore IC to a normal level. Institutions that rely on 
      ACTC as a screening test for hyperparathyroidism in MEN 1 will miss the diagnosis 
      in nearly half of patients under the age of 30. The greatest deficiency in using 
      ACTC occurs in the follow-up of patients who have undergone parathyroidectomy for 
      MEN 1. Only three of 11 recurrences were evidenced by this measurement.
FAU - Shepherd, J J
AU  - Shepherd JJ
AD  - Department of Surgery, University of Tasmania, Hobart, Australia.
FAU - Teh, B T
AU  - Teh BT
FAU - Parameswaran, V
AU  - Parameswaran V
FAU - David, R
AU  - David R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Henry Ford Hosp Med J
JT  - Henry Ford Hospital medical journal
JID - 0122304
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Calcium/*blood
MH  - Child
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism/*blood/etiology
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/*complications/genetics/pathology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Henry Ford Hosp Med J. 1992;40(3-4):186-90.