PMID- 1362404
OWN - NLM
STAT- MEDLINE
DCOM- 19930217
LR  - 20041117
IS  - 0018-0416 (Print)
IS  - 0018-0416 (Linking)
VI  - 40
IP  - 3-4
DP  - 1992
TI  - Surgical treatment of the endocrine pancreas and Zollinger-Ellison syndrome in 
      the MEN 1 syndrome.
PG  - 195-8
AB  - Islet cell neoplasia is a frequent occurrence in multiple endocrine neoplasia 
      type 1 (MEN 1). Sixteen of 27 patients with MEN 1 developed functioning endocrine 
      pancreatic tumor syndromes. Eleven of the 16 developed Zollinger-Ellison syndrome 
      and each was evaluated by a combination of computed tomography and hepatic 
      angiography to exclude hepatic metastasis and percutaneous transhepatic 
      catheterization to localize the tumor. Seven of the 11 patients were found to 
      have duodenal gastrinomas with multiple duodenal tumors in three patients. Four 
      of the 11 patients had only pancreatic gastrinomas. In addition to the 
      gastrinomas, other types of islet tumors in the pancreatic body or tail were 
      found in nine of the 11 patients. None of the patients had hepatic metastases. 
      Seven of the 11 patients were treated by distal pancreatectomy and since 1986 all 
      patients have had duodenotomies as part of the surgical exploration. Postsurgical 
      evaluation ranging from three months to 14 years indicates that 10 of 11 patients 
      have normal basal gastrin levels. We conclude that duodenal gastrinomas are 
      common in MEN 1 and can be managed successfully by appropriate operative 
      intervention.
FAU - Thompson, N W
AU  - Thompson NW
AD  - Division of Endocrine Surgery, University of Michigan Medical Center, Ann Arbor 
      48109.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Henry Ford Hosp Med J
JT  - Henry Ford Hospital medical journal
JID - 0122304
SB  - IM
MH  - Adenoma, Islet Cell/surgery
MH  - Adult
MH  - Female
MH  - Gastrinoma/surgery
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia/*surgery
MH  - Pancreatic Neoplasms/*surgery
MH  - Zollinger-Ellison Syndrome/*surgery
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Henry Ford Hosp Med J. 1992;40(3-4):195-8.