PMID- 1362760
OWN - NLM
STAT- MEDLINE
DCOM- 19930304
LR  - 20190907
IS  - 0955-3002 (Print)
IS  - 0955-3002 (Linking)
VI  - 62
IP  - 6
DP  - 1992 Dec
TI  - Radiation-induced chromosome aberrations analysed by fluorescence in situ 
      hybridization with a triple combination of composite whole chromosome-specific 
      DNA probes.
PG  - 673-8
AB  - Fluorescence in situ hybridization (FISH) with a combination of three composite 
      whole chromosome-specific DNA probes for human chromosomes 1, 4 and 12 was used 
      to analyse in vitro radiation-induced dicentrics and symmetrical translocations 
      in peripheral lymphocytes. Translocations could be rapidly and efficiently 
      detected by FISH. Their frequencies were 1.8-fold higher than the frequencies for 
      dicentrics at a given dose. The dose-response curves for translocations and 
      dicentrics were linear quadratic with a significant higher quadratic component 
      for translocations. The application of FISH for scoring stable translocations for 
      biological dosimetry of radiation exposures is discussed.
FAU - Schmid, E
AU  - Schmid E
AD  - Institut fur Strahlenbiologie, GSF-Forschungszentrum fur Umwelt und Gesundheit, 
      Neuherberg, Germany.
FAU - Zitzelsberger, H
AU  - Zitzelsberger H
FAU - Braselmann, H
AU  - Braselmann H
FAU - Gray, J W
AU  - Gray JW
FAU - Bauchinger, M
AU  - Bauchinger M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 0 (DNA Probes)
SB  - IM
MH  - Adult
MH  - Blood/*radiation effects
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1/*radiation effects
MH  - Chromosomes, Human, Pair 12/*radiation effects
MH  - Chromosomes, Human, Pair 4/*radiation effects
MH  - DNA Probes
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - In Vitro Techniques
MH  - Male
MH  - Middle Aged
MH  - Radiation Genetics
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
AID - 7L7AL0XW2CL39TE8 [pii]
AID - 10.1080/09553009214552621 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 1992 Dec;62(6):673-8. doi: 10.1080/09553009214552621.