PMID- 1363506
OWN - NLM
STAT- MEDLINE
DCOM- 19930415
LR  - 20190824
IS  - 0065-4299 (Print)
IS  - 0065-4299 (Linking)
VI  - 37
IP  - 3-4
DP  - 1992 Nov
TI  - Differentiation of the U-937 promonocytic cell line induced by phorbol myristate 
      acetate or retinoic acid: effect of aurothiomalate.
PG  - 305-10
AB  - Tissue macrophages, which participate in chronic synovial inflammation, 
      differentiate from haemopoietic precursors in bone marrow and subsequently in 
      tissue. During this process, they acquire attributes which are essential for 
      their function in inflammation. Modulation of this process may represent a means 
      of regulating inflammatory competence of macrophages in inflammatory joint 
      disease. The action of aurothiomalate (ATM), an anti-rheumatic gold compound, on 
      the differentiation of a promonocytic cell line (U937) was, therefore, examined 
      in in vitro systems. U937 cells exposed to retinoic acid (RA) for 4 days or to 
      phorbol myristate acetate (PMA) for 2 days acquired characteristics of 
      macrophages, including the capacity to produce superoxide (O2-), responsiveness 
      to formyl-methionyl-leucyl-phenylalanine (fMLP) and reduced proliferation. The 
      activity of transglutaminase also increased in RA-exposed cultures. The effect of 
      ATM exposure on acquisition of these characteristics was small and differed 
      between RA- and PMA-stimulated cells.
FAU - Joyce, D A
AU  - Joyce DA
AD  - Department of Pharmacology, University of Western Australia, Nedlands.
FAU - Steer, J H
AU  - Steer JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Agents Actions
JT  - Agents and actions
JID - 0213341
RN  - 11062-77-4 (Superoxides)
RN  - 12244-57-4 (Gold Sodium Thiomalate)
RN  - 5688UTC01R (Tretinoin)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Cell Differentiation/drug effects
MH  - Cell Line
MH  - Gold Sodium Thiomalate/*pharmacology
MH  - Humans
MH  - Monocytes/*drug effects/enzymology
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Oxygen Consumption/drug effects
MH  - Phenotype
MH  - Superoxides/metabolism
MH  - Tetradecanoylphorbol Acetate/*pharmacology
MH  - Thymidine/metabolism
MH  - Tretinoin/*pharmacology
MH  - gamma-Glutamyltransferase/metabolism
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
AID - 10.1007/BF02028124 [doi]
PST - ppublish
SO  - Agents Actions. 1992 Nov;37(3-4):305-10. doi: 10.1007/BF02028124.