PMID- 1365539
OWN - NLM
STAT- MEDLINE
DCOM- 19950209
LR  - 20051116
IS  - 1056-2044 (Print)
IS  - 1056-2044 (Linking)
VI  - 1
IP  - 3
DP  - 1992 Jun
TI  - Pathogenesis of human herpesvirus 6 (HHV-6).
PG  - 149-55
AB  - The newly isolated virus, human herpesvirus 6 (HHV-6), causes exanthem subitum 
      (or roseola infantum) as the primary infection. Liver dysfunction and 
      neurological disorders are observed during exanthem subitum. Seroepidemiological 
      studies have shown that almost all children are infected with HHV-6 about 6-24 
      months after birth. This virus also causes other diseases including lymphadenitis 
      and infectious mononucleosis-like disease. HHV-6 has cellular tropism for CD4+ 
      lymphocytes, in which it replicates in vivo. Its transmission is probably 
      airborne early in life, mainly from mother to child, because it is often secreted 
      in the saliva of healthy adults having antibody to HHV-6. Latent infection 
      follows the primary infection and the virus can often be reactivated under 
      conditions of immunosuppression such as AIDS or organ transplantations. The site 
      of its latent infection is not yet known, but could be monocytes/macrophages.
FAU - Yamanishi, K
AU  - Yamanishi K
AD  - Department of Virology, Osaka University, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Infect Agents Dis
JT  - Infectious agents and disease
JID - 9209834
RN  - 0 (DNA, Viral)
SB  - IM
MH  - DNA, Viral/analysis
MH  - Exanthema Subitum/virology
MH  - Herpesvirus 6, Human/genetics/isolation & purification/*pathogenicity
MH  - Humans
MH  - Lymphocytes/virology
RF  - 92
EDAT- 1992/06/01 00:00
MHDA- 1992/06/01 00:01
CRDT- 1992/06/01 00:00
PHST- 1992/06/01 00:00 [pubmed]
PHST- 1992/06/01 00:01 [medline]
PHST- 1992/06/01 00:00 [entrez]
PST - ppublish
SO  - Infect Agents Dis. 1992 Jun;1(3):149-55.