PMID- 1365659
OWN - NLM
STAT- MEDLINE
DCOM- 19950223
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 109
IP  - 1-2
DP  - 1992
TI  - Effect of 5-HT agonists on rats fed single diets with varying proportions of 
      carbohydrate and protein.
PG  - 212-6
AB  - Low doses of 5-HT agonists have been shown to selectively suppress carbohydrate 
      intake in rats given dietary choices. To investigate further the relationship 
      between dietary macronutrient composition and 5-HT-induced anorexia, the present 
      study examined the effects of three 5-HT agonists on rats fed single isocaloric 
      diets containing varying proportions of carbohydrate (CHO) and protein (PRO). 
      Rats were habituated to eat one of the three diets (73.5% CHO--10% PRO, 58.5% 
      CHO--25% PRO or 43.5% CHO--40% PRO) during the dark period (1900-0700 h). Saline 
      or 5-HT agonists (fluoxetine, RU 24969 and dexfenfluramine) were administered 
      intraperitoneally at 1845 hours, 15 min prior to food access. At the doses used, 
      food intake was significantly affected only during the first hour of eating. All 
      5-HT agonists caused dose-dependent decreases in food intake (P < 0.01). The 
      magnitude of decrease, however, was significantly influenced by diet composition. 
      Reduction in intake was greatest in rats fed the 73.5% CHO--10% PRO diet. Thus, 
      rats chronically fed a diet high in carbohydrate content were more sensitive to 
      the anorectic effect of 5-HT agonists than rats fed diets containing moderate to 
      low levels of carbohydrate.
FAU - Luo, S
AU  - Luo S
AD  - Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 
      Ontario, Canada.
FAU - Li, E T
AU  - Li ET
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 0 (Indoles)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 2DS058H2CF (Fenfluramine)
RN  - 2ISE72RACC (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole)
SB  - IM
MH  - Animals
MH  - Dietary Carbohydrates/*pharmacology
MH  - Dietary Proteins/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Eating/*drug effects
MH  - Fenfluramine/pharmacology
MH  - Fluoxetine/pharmacology
MH  - Indoles/pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin Receptor Agonists/*pharmacology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1007/BF02245502 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1992;109(1-2):212-6. doi: 10.1007/BF02245502.