PMID- 13677934 OWN - NLM STAT- MEDLINE DCOM- 20031125 LR - 20191210 IS - 0047-1860 (Print) IS - 0047-1860 (Linking) VI - 51 IP - 8 DP - 2003 Aug TI - [A basic study of determination matrix metalloproteinase-3 and carbohydrate in rheumatoid factor in serum for diagnosis of rheumatoid arthritis]. PG - 745-50 AB - The examination of rheumatoid factor (RF), one of the diagnostic marker of rheumatoid arthritis (RA), showed negative about 25% of patients with RA. We analyzed a matrix metalloproteinase-3 (MMP-3) and a carbohydrate in rheumatoid factor (CA.RF) for diagnosis of RA: the former is used the kit "Panaclear MMP-3[Plate]" and the latter is used the kit "Picolumi CA.RF". The basic study of these reagents showed satisfactory results. In 73.3% of seronegative RA showed positive on both MMP-3 and CA.RF levels in serum, respectively. We found that these examinations might be useful for diagnosis of RA, especially during seronegative RA. FAU - Urata, Michiyo AU - Urata M AD - Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka 812-8582. FAU - Nakamura, Nobuko AU - Nakamura N FAU - Kinoshita, Sachiko AU - Kinoshita S FAU - Kayamori, Yuzo AU - Kayamori Y FAU - Hamasaki, Naotaka AU - Hamasaki N LA - jpn PT - Evaluation Study PT - Journal Article PL - Japan TA - Rinsho Byori JT - Rinsho byori. The Japanese journal of clinical pathology JID - 2984781R RN - 0 (Biomarkers) RN - 0 (Immunoglobulin G) RN - 0 (Reagent Kits, Diagnostic) RN - EC 3.4.24.17 (Matrix Metalloproteinase 3) RN - X2RN3Q8DNE (Galactose) SB - IM MH - Adult MH - Aged MH - Arthritis, Rheumatoid/*diagnosis MH - Biomarkers/blood MH - False Negative Reactions MH - Female MH - Galactose/deficiency MH - Humans MH - Immunoglobulin G/*blood/chemistry MH - Male MH - Matrix Metalloproteinase 3/*blood MH - Middle Aged MH - *Reagent Kits, Diagnostic/standards EDAT- 2003/09/19 05:00 MHDA- 2003/12/03 05:00 CRDT- 2003/09/19 05:00 PHST- 2003/09/19 05:00 [pubmed] PHST- 2003/12/03 05:00 [medline] PHST- 2003/09/19 05:00 [entrez] PST - ppublish SO - Rinsho Byori. 2003 Aug;51(8):745-50.