PMID- 13678560
OWN - NLM
STAT- MEDLINE
DCOM- 20040106
LR  - 20191107
IS  - 1523-3812 (Print)
IS  - 1523-3812 (Linking)
VI  - 5
IP  - 5
DP  - 2003 Oct
TI  - Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: 
      significance in the elderly.
PG  - 384-90
AB  - The effects of overt hypothyroidism (HO) on cognition and mood are well 
      established, and HO is considered a common cause of reversible dementia. There is 
      now increasing evidence to suggest that subclinical hypothyroidism (ie, elevated 
      thyroid stimulating hormone in the presence of normal thyroxine concentrations) 
      may be a predisposing factor for depression, cognitive impairment, and dementia. 
      Subclinical hypothyroidism is more common than HO and is most prevalent in the 
      elderly, particularly in women. Older adults may be more vulnerable to the 
      effects of subclinical hypothyroidism, given age-related changes to the 
      hypothalamic-pituitary-thyroid axis, and there is an association between thyroid 
      status and cognitive decline and dementia in the elderly. The purpose of this 
      review is to summarize existing data on the cognitive and neuropsychiatric 
      consequences of subclinical hypothyroidism, benefits of treatment, and 
      recommendations for screening and monitoring in older adults.
FAU - Davis, Jennifer Duncan
AU  - Davis JD
AD  - Brown Medical School, Rhode Island Hospital Physicians Office Building, Suite 
      430, 110 Lockwood Street, Providence, RI 02903, USA. jdavis3@lifespan.org
FAU - Stern, Robert A
AU  - Stern RA
FAU - Flashman, Laura A
AU  - Flashman LA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Psychiatry Rep
JT  - Current psychiatry reports
JID - 100888960
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Aged
MH  - Clinical Trials as Topic
MH  - Cognition Disorders/etiology/*prevention & control/psychology
MH  - Dementia/etiology/*prevention & control/psychology
MH  - Depressive Disorder/etiology/*prevention & control/psychology
MH  - Humans
MH  - Hypothalamo-Hypophyseal System/physiopathology
MH  - Hypothyroidism/complications/drug therapy/*psychology
MH  - Pituitary-Adrenal System/physiopathology
MH  - Risk Factors
MH  - Thyroid Function Tests/methods
MH  - Thyroxine/therapeutic use
RF  - 48
EDAT- 2003/09/19 05:00
MHDA- 2004/01/07 05:00
CRDT- 2003/09/19 05:00
PHST- 2003/09/19 05:00 [pubmed]
PHST- 2004/01/07 05:00 [medline]
PHST- 2003/09/19 05:00 [entrez]
AID - 10.1007/s11920-003-0073-6 [doi]
PST - ppublish
SO  - Curr Psychiatry Rep. 2003 Oct;5(5):384-90. doi: 10.1007/s11920-003-0073-6.