PMID- 13678649
OWN - NLM
STAT- MEDLINE
DCOM- 20040812
LR  - 20191107
IS  - 1537-1891 (Print)
IS  - 1537-1891 (Linking)
VI  - 40
IP  - 3
DP  - 2003 Oct
TI  - Enoxaparin--a low molecular weight heparin, restores the altered vascular 
      reactivity of resistance arteries in aged and aged-diabetic hamsters.
PG  - 167-74
AB  - We questioned whether the low molecular weight heparin enoxaparin acts upon the 
      altered vascular reactivity of the resistance arteries in normal biological aging 
      and in aging associated with diabetes. Experiments were performed on isolated 
      resistance arteries of young (4 months old), aged (16 months old), and 
      aged-diabetic hamsters (16 months old and 5 months since streptozotocin 
      injection), and the reactivity was assessed by the myograph technique. The 
      results showed that enoxaparin (60 microg/ml) had favorable effects on the 
      vascular reactivity in aged and aged-diabetic conditions, i.e., diminished the 
      contractility of the arterial wall to 10(-8)-10(-6) M noradrenaline (NA) and to 
      K(+), and potentiated the impeded endothelium-dependent relaxation to 
      10(-8)-10(-4) M acetylcholine (ACh). The effect was more pronounced compared to 
      that produced by unfractionated heparin (UFH). These pharmacological effects 
      supplement the anticoagulant properties of enoxaparin and may be of relevance for 
      improving perfusion/circulation in the microvasculature of aged and of 
      aged-diabetic persons.
FAU - Georgescu, Adriana
AU  - Georgescu A
AD  - Institute of Cellular Biology and Pathology N.Simionescu, 8, B.P. Hasdeu Street, 
      Bucharest 79691, Romania.
FAU - Popov, Doina
AU  - Popov D
FAU - Capraru, Monica
AU  - Capraru M
FAU - Simionescu, Maya
AU  - Simionescu M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Vascul Pharmacol
JT  - Vascular pharmacology
JID - 101130615
RN  - 0 (Anticoagulants)
RN  - 0 (Blood Glucose)
RN  - 0 (Enoxaparin)
RN  - 0 (Vasoconstrictor Agents)
RN  - 0 (Vasodilator Agents)
RN  - 9005-49-6 (Heparin)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - N9YNS0M02X (Acetylcholine)
RN  - RWP5GA015D (Potassium)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Age Factors
MH  - Animals
MH  - Anticoagulants/*pharmacology
MH  - Blood Glucose/metabolism
MH  - Cholesterol/blood
MH  - Cricetinae
MH  - Diabetes Mellitus, Experimental/blood/physiopathology
MH  - Endothelium, Vascular/physiopathology
MH  - Enoxaparin/*pharmacology
MH  - Heparin/pharmacology
MH  - In Vitro Techniques
MH  - Male
MH  - Mesenteric Arteries/*drug effects/physiopathology
MH  - Muscle Contraction/drug effects
MH  - Myography
MH  - Norepinephrine/metabolism
MH  - Potassium/metabolism
MH  - Vascular Resistance/*drug effects
MH  - Vasoconstrictor Agents/pharmacology
MH  - Vasodilator Agents/pharmacology
EDAT- 2003/09/19 05:00
MHDA- 2004/08/13 05:00
CRDT- 2003/09/19 05:00
PHST- 2003/09/19 05:00 [pubmed]
PHST- 2004/08/13 05:00 [medline]
PHST- 2003/09/19 05:00 [entrez]
AID - S1537189103000417 [pii]
AID - 10.1016/s1537-1891(03)00041-7 [doi]
PST - ppublish
SO  - Vascul Pharmacol. 2003 Oct;40(3):167-74. doi: 10.1016/s1537-1891(03)00041-7.