PMID- 13678793
OWN - NLM
STAT- MEDLINE
DCOM- 20040430
LR  - 20191107
IS  - 0928-0987 (Print)
IS  - 0928-0987 (Linking)
VI  - 20
IP  - 1
DP  - 2003 Sep
TI  - Study of the biodegradation and in vivo biocompatibility of novel biomaterials.
PG  - 53-61
AB  - The degradation of two rosin-based biomaterials, the glycerol ester of maleic 
      rosin (GMR) and the pentaerythritol ester of maleic rosin (PMR), was examined in 
      vitro in phosphate-buffered saline at pH 7.4 and in vivo in a subcutaneous rat 
      model. Free films of the two biomaterials with mean thickness 0.4+/-0.02 mm were 
      used for the study. The initial biocompatibility was followed by microscopic 
      examination of the inflammatory tissue response to the implanted films. Sample 
      weight loss and molecular weight decline of the free films was used to monitor 
      the degradation quantitatively, while surface morphological changes were analysed 
      for qualitative estimation. Biocompatibility response was followed on 
      post-operative days 7, 14, 21 and 28 and compared with those of 
      poly(DL-lactic-co-glycolic acid) (PLGA) (50:50) films. Both biomaterials showed 
      slow in vitro degradation when compared with the in vivo rate. The mechanism 
      followed was, however, bulk degradation of the films. The penta-esterified form 
      of maleic rosin was observed to degrade more rapidly than glycerol esterified 
      maleic rosin. The acute and subacute inflammatory reactions were characterized by 
      fibrosis at the end of 28 days. The biomaterials showed reasonable tissue 
      tolerance to the extent evaluated. There was a total absence of tissue necrosis 
      or abscess formation for all implanted films. The response, although not 
      identical to that of PLGA, is reasonable, promising new drug delivery 
      applications for rosin biomaterials.
FAU - Fulzele, S V
AU  - Fulzele SV
AD  - Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, 
      440010, Nagpur, India. fsuniket@yahoo.com
FAU - Satturwar, P M
AU  - Satturwar PM
FAU - Dorle, A K
AU  - Dorle AK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharm Sci
JT  - European journal of pharmaceutical sciences : official journal of the European 
      Federation for Pharmaceutical Sciences
JID - 9317982
RN  - 0 (Biocompatible Materials)
RN  - 0 (Drug Implants)
RN  - 0 (Esters)
RN  - 0 (Polymers)
RN  - 0 (Resins, Plant)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 88S87KL877 (rosin)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemistry/*metabolism
MH  - Biodegradation, Environmental
MH  - Chromatography, Gel
MH  - Drug Implants/metabolism
MH  - Drug Stability
MH  - Esters
MH  - In Vitro Techniques
MH  - Lactic Acid/chemistry
MH  - Male
MH  - Microscopy, Electron, Scanning
MH  - Molecular Weight
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Resins, Plant/chemistry/*metabolism
EDAT- 2003/09/19 05:00
MHDA- 2004/05/01 05:00
CRDT- 2003/09/19 05:00
PHST- 2003/09/19 05:00 [pubmed]
PHST- 2004/05/01 05:00 [medline]
PHST- 2003/09/19 05:00 [entrez]
AID - S0928098703001684 [pii]
AID - 10.1016/s0928-0987(03)00168-4 [doi]
PST - ppublish
SO  - Eur J Pharm Sci. 2003 Sep;20(1):53-61. doi: 10.1016/s0928-0987(03)00168-4.