PMID- 13680298
OWN - NLM
STAT- MEDLINE
DCOM- 20040123
LR  - 20200228
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 48
IP  - 10
DP  - 2003
TI  - Power of association test for detecting minor histocompatibility gene causing 
      graft-versus-host disease following bone marrow transplantation [correction].
PG  - 502-507
LID - 10.1007/s10038-003-0065-8 [doi]
AB  - Incompatibility of minor histocompatibility antigen (mHa) is a major cause of 
      acute graft-versus-host disease (GVHD) following bone marrow transplantation in 
      human leukocyte antigen (HLA)-matched donor-recipient pairs. To avoid acute GVHD, 
      as many mHa genes as possible need to be identified. In this study, we introduce 
      a comparison of two proportions as an association test for detecting mHa genes in 
      HLA-matched pairs with and without GVHD. Assuming multiple mHa loci, each with 
      two alleles, we evaluated the effects of (1). minor allele frequency of the mHa 
      locus of interest (denoted by p), and (2). probability of GVHD developing in a 
      donor-recipient pair being incompatible at an mHa locus (denoted by r) on the 
      powers of association tests for unrelated pairs and for sib pairs. Our results 
      showed that based on a candidate gene approach, an mHa gene with high p and r 
      values can be detected by the association test with a small sample size. 
      Application of the present method to the Japanese population revealed that the 
      association test for unrelated pairs is more suitable for detecting an mHa gene 
      with a high r value than that for sib pairs. The present method will be helpful 
      to researchers who evaluate the power of association study in advance.
FAU - Ohashi, Jun
AU  - Ohashi J
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan. juno-tky@umin.ac.jp.
AD  - Department of Molecular Biology and Genetics, Cornell University, 227 
      Biotechnology Building, Ithaca, NY , 14853, USA. juno-tky@umin.ac.jp.
FAU - Maruya, Etsuko
AU  - Maruya E
AD  - HLA Laboratory, NPO, Kyoto, Japan.
FAU - Tokunaga, Katsushi
AU  - Tokunaga K
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Saji, Hiroh
AU  - Saji H
AD  - HLA Laboratory, NPO, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030912
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (Minor Histocompatibility Antigens)
SB  - IM
EIN - J Hum Genet. 2003;48(11):603
MH  - Bone Marrow Transplantation/*immunology
MH  - Data Interpretation, Statistical
MH  - *Genetic Techniques
MH  - Graft vs Host Disease/etiology/*genetics
MH  - Humans
MH  - Minor Histocompatibility Antigens/*genetics/metabolism
MH  - Models, Genetic
MH  - Research Design
EDAT- 2003/09/19 05:00
MHDA- 2004/01/24 05:00
CRDT- 2003/09/19 05:00
PHST- 2003/06/03 00:00 [received]
PHST- 2003/07/22 00:00 [accepted]
PHST- 2003/09/19 05:00 [pubmed]
PHST- 2004/01/24 05:00 [medline]
PHST- 2003/09/19 05:00 [entrez]
AID - 10.1007/s10038-003-0065-8 [pii]
AID - 10.1007/s10038-003-0065-8 [doi]
PST - ppublish
SO  - J Hum Genet. 2003;48(10):502-507. doi: 10.1007/s10038-003-0065-8. Epub 2003 Sep 
      12.