PMID- 13680553
OWN - NLM
STAT- MEDLINE
DCOM- 20040319
LR  - 20191210
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 9
IP  - 4
DP  - 2003 Aug
TI  - Plasma endothelin-1 levels and clinical correlates in patients with chronic heart 
      failure.
PG  - 318-24
AB  - BACKGROUND: Endothelin-1 (ET-1) is a potent vasoconstrictor peptide, and patients 
      with chronic heart failure (CHF) are reported to have high plasma ET-1 levels. 
      The aim of this study was to investigate the relation between plasma ET-1 levels 
      and clinical correlates in patients with CHF. The effects of maximal exercise on 
      plasma ET-1 levels were also investigated. METHODS: Plasma concentrations of 
      ET-1, norepinephrine, and atrial and brain natriuretic peptide (ANP and BNP) both 
      at rest and after maximal cardiopulmonary exercise test were determined in 100 
      patients with CHF (60 +/- 12 years, New York Heart Association [NYHA] class 
      I-III, left ventricular ejection fraction [LVEF]=36 +/- 8%, peak oxygen uptake 
      [VO2] = 18.2 +/- 5.0 mL/min/kg) and 27 controls. RESULTS: Patients with NYHA 
      class II and III CHF had higher ET-1 levels (controls, NYHA class I, II, III: 2.1 
      +/- 0.6, 2.1 +/- 1.0, 2.6 +/- 0.9, 3.4 +/- 0.8 pg/mL, analysis of variance P 
      <.0001). Maximal exercise did not alter ET-1 levels in controls or in each CHF 
      subgroup. When all CHF patients were analyzed together, cardiothoracic ratio 
      (P<.01), peak VO2 (P<.001), plasma norepinephrine (P<.01), plasma ANP (P<.01), 
      and plasma BNP (P<.001) were significantly related with resting ET-1 levels on 
      univariate analysis. Multivariate analysis revealed peak VO2 and plasma BNP 
      levels showed an independent and significant relationship with the resting plasma 
      ET-1 levels. CONCLUSIONS: Resting ET-1 levels were increased in symptomatic 
      patients with CHF, and maximal exercise did not increase ET-1 levels. Peak VO2 
      and plasma BNP levels were independently associated with resting plasma ET-1 
      levels in patients with CHF.
FAU - Kinugawa, Toru
AU  - Kinugawa T
AD  - Department of Cardiovascular Medicine, Tottori University Faculty of Medicine, 
      Yonago, Japan.
FAU - Kato, Masahiko
AU  - Kato M
FAU - Ogino, Kazuhide
AU  - Ogino K
FAU - Osaki, Shuichi
AU  - Osaki S
FAU - Igawa, Osamu
AU  - Igawa O
FAU - Hisatome, Ichiro
AU  - Hisatome I
FAU - Shigemasa, Chiaki
AU  - Shigemasa C
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Biomarkers)
RN  - 0 (Endothelin-1)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Aged
MH  - Anaerobic Threshold/physiology
MH  - Atrial Natriuretic Factor/blood
MH  - Biomarkers/blood
MH  - Chronic Disease
MH  - Endothelin-1/*blood
MH  - Exercise/physiology
MH  - Female
MH  - Heart Failure/*blood/etiology/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/blood
MH  - Norepinephrine/blood
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - Systole/physiology
MH  - Ventricular Dysfunction, Left/blood/etiology/physiopathology
EDAT- 2003/09/19 05:00
MHDA- 2004/03/20 05:00
CRDT- 2003/09/19 05:00
PHST- 2003/09/19 05:00 [pubmed]
PHST- 2004/03/20 05:00 [medline]
PHST- 2003/09/19 05:00 [entrez]
AID - S107191640300054X [pii]
AID - 10.1054/jcaf.2003.39 [doi]
PST - ppublish
SO  - J Card Fail. 2003 Aug;9(4):318-24. doi: 10.1054/jcaf.2003.39.