PMID- 1369606
OWN - NLM
STAT- MEDLINE
DCOM- 19950720
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 56
IP  - 6
DP  - 1992 Dec
TI  - Increased circulating interleukin-1 and interleukin-6 after 
      intracerebroventricular injection of lipopolysaccharide.
PG  - 935-8
AB  - Recently, it was demonstrated that intracerebroventricular (icv) injection of 
      interleukin-1 (IL-1) stimulated circulating interleukin-6 (IL-6) to a greater 
      degree than intravenous (i.v.) injection of IL-1. The goal of this study was to 
      compare the efficacy of lipopolysaccharide (LPS), injected both icv and i.v., on 
      circulating concentrations of IL-1 and IL-6. Both i.v. and icv injection of LPS 
      stimulated plasma levels of IL-1 to a similar degree. However, i.v. injection of 
      LPS was significantly more efficacious than icv injection of LPS in elevating 
      circulating IL-6. These results demonstrate that like i.v. injection of LPS, icv 
      injection of LPS stimulates plasma levels of IL-1 and IL-6. Increases in 
      circulating cytokines during infectious diseases which are limited to the central 
      nervous system may serve to activate peripheral functions of an acute phase 
      response.
FAU - Gottschall, P E
AU  - Gottschall PE
AD  - US-Japan Biomedical Research Laboratories, Tulane University, Hebert Center, 
      Belle Chasse, La 70037, USA.
FAU - Komaki, G
AU  - Komaki G
FAU - Arimura, A
AU  - Arimura A
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Animals
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Interleukin-1/*blood
MH  - Interleukin-6/*blood
MH  - Lipopolysaccharides/administration & dosage/cerebrospinal fluid/*pharmacology
MH  - Male
MH  - Radioligand Assay
MH  - Rats
MH  - Time Factors
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
AID - 10.1159/000126328 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1992 Dec;56(6):935-8. doi: 10.1159/000126328.