PMID- 1370529
OWN - NLM
STAT- MEDLINE
DCOM- 19920214
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 175
IP  - 1
DP  - 1992 Jan 1
TI  - c-kit ligand: a unique potentiator of mediator release by human lung mast cells.
PG  - 237-44
AB  - Mast cells (MC) play a central role in extrinsic allergic reactions such as 
      asthma and may participate in other inflammatory and fibrotic processes. However, 
      with the exception of immunoglobulin E (IgE) receptor-dependent stimulation, no 
      secretagogues of human lung MC have yet been described. It is also unclear 
      whether mediator release can be regulated by certain cytokines as demonstrated 
      previously in basophils and other human inflammatory effector cells. Here, we 
      show that the c-kit ligand (KL), a recently identified stem cell growth factor, 
      at concentrations 10-100 times lower than that required to promote cell 
      proliferation, enhances the release of histamine and leukotriene C4 in response 
      to IgE receptor crosslinking of human lung MC. KL does not induce mediator 
      release per se, but increases the sensitivity of MC to anti-IgE receptor 
      stimulation and also enhances mediator release to maximally effective 
      concentrations of anti-IgE receptor antibody. By contrast, a large number of 
      cytokines examined, including the mast cell growth factors/agonists in rodents, 
      interleukin 3 (IL-3), IL-4, IL-9, and nerve growth factor, were ineffective in 
      this respect. These findings suggest a unique role of KL in regulating effector 
      functions of human mucosal MC.
FAU - Bischoff, S C
AU  - Bischoff SC
AD  - Institute of Clinical Immunology, Inselspital, Bern, Switzerland.
FAU - Dahinden, C A
AU  - Dahinden CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (Cytokines)
RN  - 0 (Hematopoietic Cell Growth Factors)
RN  - 0 (Receptors, Fc)
RN  - 0 (Receptors, IgE)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Stem Cell Factor)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antigens, Differentiation, B-Lymphocyte/physiology
MH  - Cells, Cultured
MH  - Cytokines/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hematopoietic Cell Growth Factors/genetics/*pharmacology
MH  - Humans
MH  - Immunoglobulin E/physiology
MH  - Kinetics
MH  - Lung/*physiology
MH  - Mast Cells/drug effects/*physiology
MH  - Molecular Sequence Data
MH  - Receptors, Fc/physiology
MH  - Receptors, IgE
MH  - Recombinant Proteins/pharmacology
MH  - Stem Cell Factor
PMC - PMC2119079
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
PMCR- 1992/07/01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PHST- 1992/07/01 00:00 [pmc-release]
AID - 92113465 [pii]
AID - 10.1084/jem.175.1.237 [doi]
PST - ppublish
SO  - J Exp Med. 1992 Jan 1;175(1):237-44. doi: 10.1084/jem.175.1.237.