PMID- 1371901
OWN - NLM
STAT- MEDLINE
DCOM- 19920408
LR  - 20190509
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 97
IP  - 3
DP  - 1992 Mar
TI  - Immunohistologic demonstration of myocardial proteins with applications.
PG  - 376-80
AB  - The authors used antibodies specific for creatine kinase MB isoenzyme (CK-MB) and 
      myosin light chain-1 (MLC-1) for immunohistologic staining. At appropriate 
      dilutions of antibody, frozen sections of human heart muscle were positive for 
      both CK-MB and MLC-1, whereas sections of human skeletal muscle were negative for 
      both proteins. Staining for both CK-MB and MLC-1 also was demonstrated in an 
      immature teratoma. Furthermore, staining was localized to the 
      rhabdomyosarcomatous elements within the teratoma; other components of the tumor 
      did not stain for CK-MB or MLC-1. Biopsies of skeletal muscle revealed that 
      regenerative, but not intact normal or degenerating, fibers also contained CK-MB 
      and MLC-1. Immunohistologic stains for CK-MB and MLC-1 may be useful as tumor 
      markers and as markers for regenerative muscle fibers.
FAU - Emancipator, K
AU  - Emancipator K
AD  - Clinical Pathology Department, Warren G. Magnuson Clinical Center, National 
      Institutes of Health, Bethesda, Maryland 20892.
FAU - Urankar-Nagy, N
AU  - Urankar-Nagy N
FAU - Leonard, K A
AU  - Leonard KA
FAU - Bradford, G
AU  - Bradford G
FAU - Emancipator, S N
AU  - Emancipator SN
LA  - eng
GR  - AI-31230/AI/NIAID NIH HHS/United States
GR  - DK-38544/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Isoenzymes)
RN  - 0 (Muscle Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - EC 3.6.4.1 (Myosins)
SB  - IM
MH  - Biopsy
MH  - Creatine Kinase/analysis
MH  - Humans
MH  - *Immunologic Techniques
MH  - Isoenzymes
MH  - Muscle Proteins/*analysis
MH  - Muscles/chemistry/pathology/physiology
MH  - Myocardium/*chemistry
MH  - Myosins/analysis/chemistry
MH  - Neoplasm Proteins/analysis
MH  - Platelet-Derived Growth Factor/analysis
MH  - Regeneration
MH  - Rhabdomyosarcoma/chemistry
MH  - Staining and Labeling
MH  - Teratoma/chemistry
EDAT- 1992/03/01 00:00
MHDA- 1992/03/01 00:01
CRDT- 1992/03/01 00:00
PHST- 1992/03/01 00:00 [pubmed]
PHST- 1992/03/01 00:01 [medline]
PHST- 1992/03/01 00:00 [entrez]
AID - 10.1093/ajcp/97.3.376 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 1992 Mar;97(3):376-80. doi: 10.1093/ajcp/97.3.376.