PMID- 1372694 OWN - NLM STAT- MEDLINE DCOM- 19920427 LR - 20131121 IS - 0027-5107 (Print) IS - 0027-5107 (Linking) VI - 278 IP - 2-3 DP - 1992 Feb-Mar TI - The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides with triethylenemelamine. PG - 127-30 AB - A micronucleus assay using mouse peripheral blood and supravital staining with acridine orange (AO) was validated by two laboratories on triethylenemelamine-treated mice. Dose- and time-dependent increases in micronucleated peripheral reticulocytes were observed. This new method can be used as an alternative to the conventional bone marrow micronucleus assay. FAU - Yamamura, E AU - Yamamura E AD - Toxicology Laboratories, Yoshitomi Pharmaceutical Industries, Ltd., Fukuoka-ken, Japan. FAU - Hirono, H AU - Hirono H FAU - Takeuchi, M AU - Takeuchi M FAU - Kojima, M AU - Kojima M FAU - Aoki, S AU - Aoki S LA - eng PT - Journal Article PL - Netherlands TA - Mutat Res JT - Mutation research JID - 0400763 RN - 0 (Mutagens) RN - 50SG953SK6 (Mitomycin) RN - F30N4O6XVV (Acridine Orange) RN - F7IY6HZG9D (Triethylenemelamine) SB - IM MH - Acridine Orange MH - Animals MH - Dose-Response Relationship, Drug MH - Male MH - Mice MH - Mice, Inbred Strains MH - Micronucleus Tests/methods MH - Mitomycin/toxicity MH - Mutagens/*toxicity MH - Reticulocytes/*drug effects MH - Triethylenemelamine/*toxicity EDAT- 1992/02/01 00:00 MHDA- 1992/02/01 00:01 CRDT- 1992/02/01 00:00 PHST- 1992/02/01 00:00 [pubmed] PHST- 1992/02/01 00:01 [medline] PHST- 1992/02/01 00:00 [entrez] AID - 0165-1218(92)90222-L [pii] PST - ppublish SO - Mutat Res. 1992 Feb-Mar;278(2-3):127-30.