PMID- 1373339
OWN - NLM
STAT- MEDLINE
DCOM- 19920521
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 69
IP  - 9
DP  - 1992 May 1
TI  - Abnormal humoral immune response to mucosal antigenic stimulation in patients 
      with lung cancer.
PG  - 2252-7
AB  - Previous studies have suggested an inverse relationship between atopy and cancer 
      of mucosal surfaces. Atopy is classically assessed by detecting specific 
      immunoglobulin E (IgE) antibodies against inhalant allergens. However, 
      Platts-Mills recently proposed that atopy is the ability of an organism to 
      recognize and to respond to limited doses of allergens presented at the mucosal 
      level by producing not only IgE, but also immunoglobulin A and immunoglobulin G 
      (IgG) antibodies. The authors compared the prevalence of atopy in 103 patients 
      with lung cancer (a model of mucosal cancer), 51 patients with chronic 
      obstructive pulmonary disease matched for age, sex, and smoking habits with 
      patients with lung cancer, and 102 healthy control subjects. The authors 
      investigated whether the IgG response to antigens presented at the mucosal level, 
      exacerbated in atopic subjects, might inversely be decreased in patients with 
      lung cancer. Serum IgE antibodies against five common inhalant allergens 
      (Dermatophagoides pteronyssinus [Der p1], Aspergillus fumigatus, grass pollen, 
      and cat and dog danders) were detected through a radioallergosorbent test assay. 
      Serum IgG antibodies against allergens naturally presented at the mucosal level 
      (respiratory mucosa with Der p1 and digestive mucosa with betalactoglobulin [BLG] 
      and soya proteins [SP]) were measured through a solid phase enzyme-linked 
      immunosorbent assay test. Atopic status was assessed in 19 patients (18.4%) with 
      lung cancer, 9 patients (17.6%) with chronic obstructive pulmonary disease 
      (COPD), and 18 healthy control subjects (17.6%). Distributions of specific IgG 
      levels were represented on frequency histograms after natural logarithmic 
      transformation and showed reduced levels of anti-Der p1 and anti-BLG IgG in the 
      cancer population compared with the control populations but similar levels of 
      anti-SP IgG. Influence of sex, age, smoking habits, histologic type of cancer, 
      and its extent could be excluded. The authors' results show no difference in the 
      prevalence of atopy between the three groups. They document a selective, rather 
      than general, defect in the immune response initiated at the mucosal level in 
      patients with lung cancer, the most frequent mucosal cancer in man.
FAU - Michils, A
AU  - Michils A
AD  - Department of Chest Medicine, Erasme Hospital, Brussels, Belgium.
FAU - Yernault, J C
AU  - Yernault JC
FAU - Noel, E
AU  - Noel E
FAU - Gossart, B
AU  - Gossart B
FAU - Servais, G
AU  - Servais G
FAU - Duchateau, J
AU  - Duchateau J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Dust)
RN  - 0 (Epitopes)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Lactoglobulins)
RN  - 0 (Plant Proteins, Dietary)
RN  - 0 (Soybean Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Administration, Inhalation
MH  - Adult
MH  - Allergens/*immunology
MH  - Antibody Formation/immunology
MH  - Antigens, Dermatophagoides
MH  - Atrophy/immunology
MH  - Carcinoma, Bronchogenic/*immunology
MH  - Dust/adverse effects
MH  - Epitopes
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Immunoglobulin G/immunology
MH  - Lactoglobulins/immunology/pharmacology
MH  - Lung/immunology/pathology
MH  - Lung Diseases, Obstructive/immunology
MH  - Lung Neoplasms/*immunology
MH  - Male
MH  - Middle Aged
MH  - Mucous Membrane/immunology/pathology
MH  - Plant Proteins, Dietary/immunology/pharmacology
MH  - Soybean Proteins
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - 10.1002/1097-0142(19920501)69:9<2252::aid-cncr2820690907>3.0.co;2-q [doi]
PST - ppublish
SO  - Cancer. 1992 May 1;69(9):2252-7. doi: 
      10.1002/1097-0142(19920501)69:9<2252::aid-cncr2820690907>3.0.co;2-q.