PMID- 1375038
OWN - NLM
STAT- MEDLINE
DCOM- 19920623
LR  - 20220310
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 8
IP  - 5
DP  - 1992 May
TI  - The trkB tyrosine protein kinase is a receptor for neurotrophin-4.
PG  - 947-56
AB  - Neurotrophin-4 is a novel member of the nerve growth factor family of 
      neurotrophins recently isolated from Xenopus and viper DNA. We now report that 
      the Xenopus NT-4 protein (XNT-4) can mediate some of its biological properties 
      through gp145trkB, a murine tyrosine protein kinase previously identified as a 
      primary receptor for the related brain-derived neurotrophic factor (BDNF). XNT-4 
      displaces 125I-labeled BDNF from binding to cells expressing gp145trkB receptors, 
      induces their rapid phosphorylation on tyrosine residues, and causes the 
      morphologic transformation of NIH 3T3 cells when coexpressed with gp145trkB. 
      Moreover, XNT-4 induces the differentiation of PC12 cells into sympathetic-like 
      neurons only if they ectopically express gp145trkB receptors. None of these 
      biochemical or biological effects could be observed when XNT-4 was added to cells 
      expressing the related receptors. Replacement of one of the extracellular 
      cysteines (Cys-345) of gp145trkB by a serine residue prevents its activation by 
      XNT-4 but not by BDNF. Therefore, XNT-4 and BDNF may interact with at least 
      partially distinct domains within the gp145trkB receptor.
FAU - Klein, R
AU  - Klein R
AD  - Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research 
      Institute, Princeton, New Jersey 08543-4000.
FAU - Lamballe, F
AU  - Lamballe F
FAU - Bryant, S
AU  - Bryant S
FAU - Barbacid, M
AU  - Barbacid M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 21820-51-9 (Phosphotyrosine)
RN  - 42HK56048U (Tyrosine)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Adrenal Gland Neoplasms
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Binding, Competitive
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Differentiation
MH  - Cell Line
MH  - Cell Line, Transformed
MH  - Mice
MH  - Molecular Sequence Data
MH  - Mutagenesis
MH  - Nerve Growth Factors/genetics/*metabolism/pharmacology
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurons/cytology
MH  - Pheochromocytoma
MH  - Phosphorylation
MH  - Phosphotyrosine
MH  - Protein-Tyrosine Kinases/genetics/*metabolism
MH  - Receptors, Cell Surface/*metabolism
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - Tyrosine/analogs & derivatives/metabolism
MH  - Xenopus
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - 0896-6273(92)90209-V [pii]
AID - 10.1016/0896-6273(92)90209-v [doi]
PST - ppublish
SO  - Neuron. 1992 May;8(5):947-56. doi: 10.1016/0896-6273(92)90209-v.