PMID- 1375039
OWN - NLM
STAT- MEDLINE
DCOM- 19920623
LR  - 20220317
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 8
IP  - 5
DP  - 1992 May
TI  - The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde 
      axonal transport in peripheral and central neurons.
PG  - 983-93
AB  - The pattern of retrograde axonal transport of the target-derived neurotrophic 
      molecule, nerve growth factor (NGF), correlates with its trophic actions in adult 
      neurons. We have determined that the NGF-related neurotrophins, brain-derived 
      neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are also retrogradely 
      transported by distinct populations of peripheral and central nervous system 
      neurons in the adult. All three 125I-labeled neurotrophins are retrogradely 
      transported to sites previously shown to contain neurotrophin-responsive neurons 
      as assessed in vitro, such as dorsal root ganglion and basal forebrain neurons. 
      The patterns of transport also indicate the existence of neuronal populations 
      that selectively transport NT-3 and/or BDNF, but not NGF, such as spinal cord 
      motor neurons, neurons in the entorhinal cortex, thalamus, and neurons within the 
      hippocampus itself. Our observations suggest that neurotrophins are transported 
      by overlapping as well as distinct populations of neurons when injected into a 
      given target field. Retrograde transport may thus be predictive of neuronal types 
      selectively responsive to either BDNF or NT-3 in the adult, as first demonstrated 
      for NGF.
FAU - DiStefano, P S
AU  - DiStefano PS
AD  - Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591-6707.
FAU - Friedman, B
AU  - Friedman B
FAU - Radziejewski, C
AU  - Radziejewski C
FAU - Alexander, C
AU  - Alexander C
FAU - Boland, P
AU  - Boland P
FAU - Schick, C M
AU  - Schick CM
FAU - Lindsay, R M
AU  - Lindsay RM
FAU - Wiegand, S J
AU  - Wiegand SJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Animals
MH  - *Axonal Transport
MH  - Brain-Derived Neurotrophic Factor
MH  - CHO Cells
MH  - Cricetinae
MH  - Ganglia, Spinal/metabolism
MH  - Ganglia, Sympathetic/metabolism
MH  - Hippocampus/metabolism
MH  - Iodine Radioisotopes
MH  - Male
MH  - Mice
MH  - Motor Neurons/metabolism
MH  - Nerve Growth Factors/*metabolism
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neurons/*metabolism
MH  - Neurotrophin 3
MH  - Prosencephalon/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Spinal Cord/metabolism
MH  - Thalamus/metabolism
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - 0896-6273(92)90213-W [pii]
AID - 10.1016/0896-6273(92)90213-w [doi]
PST - ppublish
SO  - Neuron. 1992 May;8(5):983-93. doi: 10.1016/0896-6273(92)90213-w.