PMID- 1378163
OWN - NLM
STAT- MEDLINE
DCOM- 19920810
LR  - 20211203
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 6
IP  - 7
DP  - 1992 Jul
TI  - c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close 
      correlation with expression of myeloid-associated antigen CD13.
PG  - 662-8
AB  - Expression of human c-kit proto-oncogene and interleukin-7 receptor (IL-7R) in 
      acute lymphoblastic leukemia (ALL) cells expressing CD7 was examined by 
      Northern-blot analysis and reversed transcription polymerase chain reaction 
      (RT-PCR) assay in relation to the phenotypes. Leukemic cells from four out of 12 
      CD7+ ALL patients, all of which fulfilled the criteria of ALL in the FAB 
      classification, expressed c-kit genes. Surface CD3 (sCD3) was absent in all of 
      these cases, while cytoplasmic CD3 (cCD3) was found in the two sCD3- cases. CD3 
      epsilon transcripts were detected in one of the sCD3- cCD3- cases. IL-7R genes 
      were transcribed in the three cases with c-kit gene expression. In addition, 
      there was a good correlation between c-kit gene expression and myeloid associated 
      antigen CD13 positivity of the leukemic cells. None of the patients with c-kit 
      gene expression had mediastinal tumor. Our results show that leukemic cells in a 
      proportion of CD7+ ALL express receptors for cytokines that are secreted by bone 
      marrow stromal cells. Ligands for c-kit genes and IL-7 could play an important 
      role for the regulation of proliferation and differentiation of T-cell 
      progenitors in bone marrow.
FAU - Nishii, K
AU  - Nishii K
AD  - Second Department of Internal Medicine, Mie University School of Medicine, Tsu, 
      Japan.
FAU - Kita, K
AU  - Kita K
FAU - Miwa, H
AU  - Miwa H
FAU - Kawakami, K
AU  - Kawakami K
FAU - Nakase, K
AU  - Nakase K
FAU - Masuya, M
AU  - Masuya M
FAU - Morita, N
AU  - Morita N
FAU - Omay, S B
AU  - Omay SB
FAU - Otsuji, N
AU  - Otsuji N
FAU - Fukumoto, M
AU  - Fukumoto M
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD7)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD3 Complex)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Interleukin-7)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
RN  - EC 3.4.11.2 (CD13 Antigens)
SB  - IM
GS  - CD3&egr;
GS  - IL7R
GS  - c-kit
MH  - Antigens, CD/analysis/*metabolism
MH  - Antigens, CD7
MH  - Antigens, Differentiation, Myelomonocytic/*metabolism
MH  - Antigens, Differentiation, T-Lymphocyte/genetics/*metabolism
MH  - CD13 Antigens
MH  - CD3 Complex
MH  - Gene Expression
MH  - Genes
MH  - Humans
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins/*genetics
MH  - Proto-Oncogene Proteins c-kit
MH  - RNA, Messenger/genetics
MH  - Receptors, Antigen, T-Cell/genetics/metabolism
MH  - Receptors, Immunologic/genetics
MH  - Receptors, Interleukin-7
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
PST - ppublish
SO  - Leukemia. 1992 Jul;6(7):662-8.