PMID- 1378873
OWN - NLM
STAT- MEDLINE
DCOM- 19920825
LR  - 20190509
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 166
IP  - 2
DP  - 1992 Aug
TI  - Cytokine and acute-phase reactant levels in serum of children with cancer 
      admitted for fever and neutropenia.
PG  - 432-6
AB  - Serum concentrations of tumor necrosis factor-alpha (TNF alpha), interleukin 
      (IL)-1 beta, IL-6, and the acute-phase reactants C-reactive protein (CRP) and 
      serum amyloid A (SAA) were measured on admission in 46 neutropenic children with 
      cancer in 81 episodes of fever. The aim was to find out whether any of these 
      variables would differentiate true bacteremia from fever due to other causes. In 
      most episodes serum concentrations of TNF alpha and IL-1 beta were elevated. IL-6 
      was detectable in 68%, but the serum concentration was elevated in only 15%. SAA 
      proved to be more sensitive than CRP for the early detection of bacteremia. 
      However, not even SAA was sufficiently accurate at the individual level. We 
      conclude that the cytokine and acute-phase protein levels found were related to 
      the febrile response but did not correlate with documented bacterial etiology.
FAU - Riikonen, P
AU  - Riikonen P
AD  - Children's Hospital, University of Helsinki, Finland.
FAU - Saarinen, U M
AU  - Saarinen UM
FAU - Teppo, A M
AU  - Teppo AM
FAU - Metsarinne, K
AU  - Metsarinne K
FAU - Fyhrquist, F
AU  - Fyhrquist F
FAU - Jalanko, H
AU  - Jalanko H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Serum Amyloid A Protein)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute-Phase Proteins/*analysis
MH  - Adolescent
MH  - Bacteremia/complications/etiology
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Female
MH  - Fever of Unknown Origin/*etiology
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Interleukin-1/blood
MH  - Male
MH  - Neoplasms/*complications
MH  - Neutropenia/*etiology
MH  - Prospective Studies
MH  - Serum Amyloid A Protein/analysis
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 10.1093/infdis/166.2.432 [doi]
PST - ppublish
SO  - J Infect Dis. 1992 Aug;166(2):432-6. doi: 10.1093/infdis/166.2.432.