PMID- 1381480
OWN - NLM
STAT- MEDLINE
DCOM- 19921002
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 280
IP  - 3
DP  - 1992
TI  - Genotoxicity of 2,4,6-trichlorophenol in V79 Chinese hamster cells.
PG  - 175-9
AB  - The genotoxicity of the rodent carcinogen 2,4,6-trichlorophenol (TCP) was studied 
      without exogenous metabolic activation in V79 Chinese hamster cells. TCP did not 
      induce mutation at the hprt locus to 6-thioguanine resistance or structural 
      chromosome aberrations. However, it produced statistically significant, 
      dose-related increases in hyperdiploidy and micronuclei. From these results it 
      appears that TCP causes chromosome malsegregation as its major mode of genotoxic 
      action.
FAU - Jansson, K
AU  - Jansson K
AD  - Department of Cell Biology, University of Jyvaskyla, Finland.
FAU - Jansson, V
AU  - Jansson V
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Carcinogens)
RN  - 0 (Chlorophenols)
RN  - 0 (Mutagens)
RN  - 9H154DI0UP (Ethyl Methanesulfonate)
RN  - EC 2.4.2.8 (Hypoxanthine Phosphoribosyltransferase)
RN  - FTK8U1GZNX (Thioguanine)
RN  - MHS8C5BAUZ (2,4,6-trichlorophenol)
SB  - IM
GS  - hprt
MH  - Animals
MH  - Carcinogens/*pharmacology
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Chlorophenols/*pharmacology
MH  - Chromosome Aberrations
MH  - Cricetinae
MH  - Cricetulus
MH  - *Diploidy
MH  - Dose-Response Relationship, Drug
MH  - Drug Resistance
MH  - Ethyl Methanesulfonate/pharmacology
MH  - Hypoxanthine Phosphoribosyltransferase/genetics
MH  - Micronucleus Tests
MH  - Mutagenicity Tests
MH  - Mutagens/*pharmacology
MH  - Thioguanine/pharmacology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 0165-1218(92)90046-3 [pii]
AID - 10.1016/0165-1218(92)90046-3 [doi]
PST - ppublish
SO  - Mutat Res. 1992;280(3):175-9. doi: 10.1016/0165-1218(92)90046-3.