PMID- 1381986
OWN - NLM
STAT- MEDLINE
DCOM- 19921022
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 29
IP  - 2
DP  - 1992 Aug
TI  - Supraoptic nucleus afferents from the accessory olfactory bulb: evidence from 
      anterograde and retrograde tract tracing in the rat.
PG  - 209-20
AB  - Our earlier electrophysiological work provided evidence of a direct input to the 
      supraoptic nucleus (SON) from the olfactory bulbs; however, these experiments 
      could not determine if the input originated in the main and/or accessory portions 
      of the olfactory bulb. Here, a connection between the accessory olfactory bulb 
      (AOB) and the SON of the rat was examined using a combination of anatomic 
      techniques. We employed neurophysin immunocytochemistry to delineate the 
      morphological boundaries of the SON and the proximal arborizations of supraoptic 
      dendrites. Accessory olfactory bulb efferents to the SON were studied by 
      injection of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) 
      into the AOB. The distribution of retrogradely labeled cells within the AOB was 
      also determined after injection of either rhodamine-labeled latex microspheres 
      (rhodamine beads) or Fluoro-Gold (FG) into the SON. Neurophysin 
      immunocytochemistry revealed that SON dendrites extended beyond the generally 
      accepted boundaries of the nucleus, coursing ventrolaterally along the surface of 
      the periamygdaloid cortex. Anterograde tract tracing with WGA-HRP labeled AOB 
      efferents including a dense plexus of terminals and fibers around the ipsilateral 
      SON along the path of the ventrally projecting dendrites. Injections of 
      retrograde tracers into the SON resulted in rhodamine bead or FG labeling of 
      mitral cells throughout the ipsilateral AOB. Taken together, these anatomic 
      studies suggest a direct projection from the accessory olfactory bulb to the SON 
      of the rat and thus a vomeronasal organ to SON pathway.
FAU - Smithson, K G
AU  - Smithson KG
AD  - Department of Physiology, Michigan State University, East Lansing 48824-1117.
FAU - Weiss, M L
AU  - Weiss ML
FAU - Hatton, G I
AU  - Hatton GI
LA  - eng
GR  - NS08125/NS/NINDS NIH HHS/United States
GR  - NS09140/NS/NINDS NIH HHS/United States
GR  - NS16942/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Neurophysins)
RN  - 0 (Rhodamines)
RN  - 0 (Stilbamidines)
RN  - 0 (Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate)
RN  - 0 (Wheat Germ Agglutinins)
RN  - EC 1.11.1.- (Horseradish Peroxidase)
SB  - IM
MH  - Afferent Pathways/*anatomy & histology/cytology
MH  - Animals
MH  - Dendrites/ultrastructure
MH  - Female
MH  - Fluorescent Dyes
MH  - Horseradish Peroxidase
MH  - Immunohistochemistry
MH  - Male
MH  - Microspheres
MH  - Neurophysins/immunology
MH  - Olfactory Bulb/*anatomy & histology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Rhodamines
MH  - *Stilbamidines
MH  - Supraoptic Nucleus/*anatomy & histology
MH  - Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
MH  - Wheat Germ Agglutinins
EDAT- 1992/08/01 00:00
MHDA- 1992/08/01 00:01
CRDT- 1992/08/01 00:00
PHST- 1992/08/01 00:00 [pubmed]
PHST- 1992/08/01 00:01 [medline]
PHST- 1992/08/01 00:00 [entrez]
AID - 0361-9230(92)90028-V [pii]
AID - 10.1016/0361-9230(92)90028-v [doi]
PST - ppublish
SO  - Brain Res Bull. 1992 Aug;29(2):209-20. doi: 10.1016/0361-9230(92)90028-v.